The Disease Biophysics Group (DBG) at Harvard University is an interdisciplinary team of biologists, physicists, engineers and material scientists actively researching the structure/function relationship in cardiac, neural, and vascular smooth muscle tissue engineering.
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What's New

DBG licenses technology to Obatala Sciences August 9th, 2021

The DBG has licensed an organ-on-chip technology to New Orleans biotech Obatala Sciences. Obatala will use the technology to build disease platforms for curing obesity, diabetes, and cancer. The collaboration has been covered by businesswire in Harvard Licenses Technology to Obatala Sciences to Advance Discovery in Obesity, Diabetes, and Cancer.

DBG Lab is Operational! March 15th, 2021

After 17 years of outstanding science in Cambridge, the DBG has moved to the Engineering School’s new campus in Allston. As of March 2, the lab is fully operational and has resumed experiments. Thank you to all alumni and current personnel for constantly raising the bar. Stand by for the next chapter of DBG science!

Congratulations to Dr. Megan McCain! March 10th, 2021

Our congratulations go out to DBG alumna, Dr. Megan McCain, who has recently received tenure at University of Southern California!

Farewell to Dr. Suhwan Kim! January 13th, 2021

Congratulations to Dr. Suhwan Kim, who has accepted a position as an Assistant Professor in the Department of Chemical Engineering at Dong-A University in Basun, South Korea! Dr. Kim was an integral part of our brain team for over a year as a postdoctoral fellow. We wish him the best on this next step in his career!

Inaugural Issue — Biophysics Reviews! January 4th, 2021

Dr. Kevin Kit Parker launched Biophysics Reviews, a new peer-reviewed journal for the biophysics research community on December 14. Produced by scientific publisher AIP Publishing, the aims to expand “on the tradition of excellence set by Applied Physics Reviews (APR) by publishing high impact, cutting edge research and reviews that are valuable for both emerging and experienced researchers”.

1. KK Parker, L Longobardi, A Sulicz. “Welcome to Biophysics Reviews, a big tent for the biophysics community”. Biophysics Reviews. 14 Dec 2020; 1(1); 010401.

Featured Publications

145. Lee KY, Nguyen HT, Setiawati A, Nam S-J, Kim M, Ko I-G, Jung WH, Parker KK* , Kim C-J,* and Shin KW* An Extracellular Matrix-Liposome Composite, a Novel Extracellular Matrix Delivery System for Accelerated Tissue Regeneration. Adv Healthc Mater. 2021 Nov 20: e2101599. doi: 10.1002/adhm.202101599. Epub ahead of print. PMID: 34800312.

144. Ziad AT, Zimmerman JF, Rao J, Sieiro D, McNamara HM, Cherrier T, Rodriguez-delaRosa A, Hick-Colin A, Bousson F, Fugier-Schmucker C, Marchianoi F, Habermanni B, Chala J, Nesmith AP, Gapon, Svetlana, Wagner E, Gupta VA, Bassel-Dubyk R, Olsonk EN, Cohen AE, Parker KK, and Pourquiea O. Prednisolone Rescues Duchenne Muscular Dystrophy Phenotypes in Human Pluripotent Stem Cell–Derived Skeletal Muscle in Vitro. PNAS. Jul 2021; 118(28) 1-12. doi: PMID: 34260377.

143. Glieberman AL, Pope BD, Melton DA, Parker KK.Building Biomimetic Potency Tests for Islet Transplantation. Diabetes. Feb 2021; 70(2); 347-363. doi: 10.2337/db20-0297. PMID: 33472944.

142. Parker KK, Longobardi L, Sulicz A. Welcome to Biophysics Reviews, a big tent for the biophysics community. Biophysics Reviews. 14 Dec 2020; 1(1); 010401. DOI: 10.1063/5.0036408. [Editorial]

141. Pope BD, Warren CR, Dahl MO, Pizza CV, Henze DE, Sinatra NR, Gonzalez GM, Chang H, Liu Q, Gleiberman AL, Ferrier JP, Cowan CA, Parker KK. Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes in vitro. Lab on a Chip. 21 Sept 2020; PMID: 33034335

140. Yadid M, Lind JU, Ardoña HAM, Sheehy SP, Dickinson LE, Eweje F, Bastings MCB, Pope B, O’Connor BB, Straubhaar JR, Budnik B, Kleber AG, Parker KK. Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip. Science Translational Medicine. 2020 Oct 14; 12(565); eaax8005. doi: 10.1126/scitranslmed.aax8005. PMID: 33055246. [Cover]

139. Ahn S, Chantre CO, Ardoña HAM, Gonzalez GM, Campbell PH, Parker KK.Biomimetic and estrogenic fibers promote tissue repair in mice and human skin via estrogen receptor β. Biomaterials. 2020 Oct; 255:120149. doi: 10.1016/j.biomaterials.2020.120149. Epub 2020 May 28. PMID: 32521331. Supplemental materials.