http://diseasebiophysics.seas.harvard.edu Disease Biophysics Group Mon, 30 Apr 2012 21:43:27 +0000 http://wordpress.org/?v=2.9.2 en hourly 1 http://diseasebiophysics.seas.harvard.edu/2012/02/1096/ http://diseasebiophysics.seas.harvard.edu/2012/02/1096/#comments Wed, 29 Feb 2012 22:34:10 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=1096 43. Desplantez T, McCain ML, Beauchamp P, Rigoli G, Rothen-Rutishauser B, Parker KK, Kleber AG. Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current. Cardiovasc Res. 2012;94:58-65.

]]> http://diseasebiophysics.seas.harvard.edu/2012/02/1096/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2012/01/042-modeling-of-cardiac-muscle-thin-films-pre-stretch-passive-and-active-behavior/ http://diseasebiophysics.seas.harvard.edu/2012/01/042-modeling-of-cardiac-muscle-thin-films-pre-stretch-passive-and-active-behavior/#comments Thu, 19 Jan 2012 16:40:55 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=851 42. Shim J, Grosberg A, Nawroth JC, Parker KK, Bertoldi K. Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior. J. Biomech. 2012;45:832-841.

]]> http://diseasebiophysics.seas.harvard.edu/2012/01/042-modeling-of-cardiac-muscle-thin-films-pre-stretch-passive-and-active-behavior/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2011/12/the-role-of-mechanical-forces-in-guiding-tissue-differentiation/ http://diseasebiophysics.seas.harvard.edu/2011/12/the-role-of-mechanical-forces-in-guiding-tissue-differentiation/#comments Wed, 14 Dec 2011 01:06:15 +0000 chambers http://diseasebiophysics.seas.harvard.edu/2011/12/the-role-of-mechanical-forces-in-guiding-tissue-differentiation/ 41. Sheehy SP, Parker KK. The Role of Mechanical Forces in Guiding Tissue Differentiation. In: Bernstein H, editor. Tissue Engineering in Regenerative Medicine. Springer; 2011:77-97.

]]> http://diseasebiophysics.seas.harvard.edu/2011/12/the-role-of-mechanical-forces-in-guiding-tissue-differentiation/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2011/12/cyclic-strain-induces-dual-mode-endothelial-mesenchymal-transformation-of-the-cardiac-valve/ http://diseasebiophysics.seas.harvard.edu/2011/12/cyclic-strain-induces-dual-mode-endothelial-mesenchymal-transformation-of-the-cardiac-valve/#comments Tue, 13 Dec 2011 16:06:29 +0000 chambers http://diseasebiophysics.seas.harvard.edu/2011/12/cyclic-strain-induces-dual-mode-endothelial-mesenchymal-transformation-of-the-cardiac-valve/ 40. Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA, Parker KK. Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. PNAS. 2011;108:19943-19948.

]]> http://diseasebiophysics.seas.harvard.edu/2011/12/cyclic-strain-induces-dual-mode-endothelial-mesenchymal-transformation-of-the-cardiac-valve/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2011/11/802/ http://diseasebiophysics.seas.harvard.edu/2011/11/802/#comments Thu, 17 Nov 2011 08:06:03 +0000 chambers http://diseasebiophysics.seas.harvard.edu/2011/11/802/ 39. McCain ML, Desplantez T, Geisse NA, Rothen-Rutishauser B, Oberer H, Parker KK, Kleber AG. Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance. Am J Physiol Heart Circ Physiol. 2012;302:H443-H450.

]]> http://diseasebiophysics.seas.harvard.edu/2011/11/802/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2011/11/038-a-simple-model-for-nanofiber-formation-by-rotary-jet-spinning/ http://diseasebiophysics.seas.harvard.edu/2011/11/038-a-simple-model-for-nanofiber-formation-by-rotary-jet-spinning/#comments Thu, 17 Nov 2011 07:57:58 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=792 38. Mellado P, McIlwee HA, Badrossamay MR, Goss JA, Mahadevan L, Parker KK. A simple model for nanofiber formation by rotary jet-spinning. Appl Phys Lett. 2011;99:203107.

]]> http://diseasebiophysics.seas.harvard.edu/2011/11/038-a-simple-model-for-nanofiber-formation-by-rotary-jet-spinning/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2011/11/ensembles-of-engineered-cardiac-tissues-for-physiological-and-pharmacological-study-heart-on-a-chip/ http://diseasebiophysics.seas.harvard.edu/2011/11/ensembles-of-engineered-cardiac-tissues-for-physiological-and-pharmacological-study-heart-on-a-chip/#comments Mon, 14 Nov 2011 15:35:03 +0000 chambers http://diseasebiophysics.seas.harvard.edu/2011/11/ensembles-of-engineered-cardiac-tissues-for-physiological-and-pharmacological-study-heart-on-a-chip/ 37. Grosberg A, Alford PW, McCain ML, Parker KK. Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip. Lab Chip. 2011;11(24):4165-4173.

]]> http://diseasebiophysics.seas.harvard.edu/2011/11/ensembles-of-engineered-cardiac-tissues-for-physiological-and-pharmacological-study-heart-on-a-chip/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2011/10/36-vascular-smooth-muscle-contractility-depends-on-cell-shape/ http://diseasebiophysics.seas.harvard.edu/2011/10/36-vascular-smooth-muscle-contractility-depends-on-cell-shape/#comments Wed, 12 Oct 2011 20:17:28 +0000 chambers http://diseasebiophysics.seas.harvard.edu/2011/10/36-vascular-smooth-muscle-contractility-depends-on-cell-shape/ 36. Alford PW, Nesmith AP, Seywerd, JN, Grosberg A, Parker KK. Vascular smooth muscle contractility depends on cell shape. Integr. Biol. 2011;3(11):1063-1070.

]]> http://diseasebiophysics.seas.harvard.edu/2011/10/36-vascular-smooth-muscle-contractility-depends-on-cell-shape/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2011/09/755/ http://diseasebiophysics.seas.harvard.edu/2011/09/755/#comments Fri, 30 Sep 2011 09:40:39 +0000 kkparker http://diseasebiophysics.seas.harvard.edu/2011/09/755/ 35. Dvir T, Timko BP, Brigham MD, Naik SR, Karajanagi SS, Levy O, Jin H, Parker KK, Langer R, Kohane DS. Nanowired three-dimensional cardiac patches. Nat Nanotechnol. 2011;6:720-725.

]]> http://diseasebiophysics.seas.harvard.edu/2011/09/755/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2011/07/plos-one-tbi/ http://diseasebiophysics.seas.harvard.edu/2011/07/plos-one-tbi/#comments Fri, 29 Jul 2011 13:01:03 +0000 kkparker http://diseasebiophysics.seas.harvard.edu/?p=715 34. Hemphill MA, Dabiri BE, Gabriele S, Kerscher L, Franck C, Goss JA, Alford PW, Parker KK. A possible role for integrin signaling in diffuse axonal injury. PLoS ONE. 2011;6:e22899.

]]> http://diseasebiophysics.seas.harvard.edu/2011/07/plos-one-tbi/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2011/07/707/ http://diseasebiophysics.seas.harvard.edu/2011/07/707/#comments Fri, 15 Jul 2011 20:21:30 +0000 kkparker http://diseasebiophysics.seas.harvard.edu/?p=707 33. Alford PW, Dabiri BE, Goss JA, Hemphill MA, Brigham MD, Parker KK. Blast-induced phenotypic switching in cerebral vasospasm. PNAS. 2011;108:12705-12710

]]> http://diseasebiophysics.seas.harvard.edu/2011/07/707/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2011/05/mechanotransduction-the-role-of-mechanical-stress-myocyte-shape-and-cytoskeletal-architecture-on-cardiac-function-invited-review/ http://diseasebiophysics.seas.harvard.edu/2011/05/mechanotransduction-the-role-of-mechanical-stress-myocyte-shape-and-cytoskeletal-architecture-on-cardiac-function-invited-review/#comments Thu, 05 May 2011 20:38:19 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=692 32. McCain ML, Parker KK. Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. Pflugers Arch – Eur J Physiol. 2011;462:89–104.

]]> http://diseasebiophysics.seas.harvard.edu/2011/05/mechanotransduction-the-role-of-mechanical-stress-myocyte-shape-and-cytoskeletal-architecture-on-cardiac-function-invited-review/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2011/02/031-self-organization-of-muscle-cell-structure-and-function/ http://diseasebiophysics.seas.harvard.edu/2011/02/031-self-organization-of-muscle-cell-structure-and-function/#comments Mon, 28 Feb 2011 23:55:17 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=625 31. Grosberg A, Kuo P-L, Guo C-L, Geisse NA, Bray M-A, Adams WJ, Sheehy SP, Parker KK. Self-organization of muscle cell structure and function. PLoS Comput Biol. 2011;7:e1001088.

]]> http://diseasebiophysics.seas.harvard.edu/2011/02/031-self-organization-of-muscle-cell-structure-and-function/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2011/02/62/ http://diseasebiophysics.seas.harvard.edu/2011/02/62/#comments Mon, 28 Feb 2011 23:25:04 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=620 30. Pong T, Adams WJ, Bray MA, Feinberg AW, Sheehy SP, Werdich AA, Parker KK. Hierarchical architecture influences calcium dynamics in engineered cardiac muscle. Exp Biol Med. 2011;236:366-373

]]> http://diseasebiophysics.seas.harvard.edu/2011/02/62/feed/ 1 http://diseasebiophysics.seas.harvard.edu/2010/08/425/ http://diseasebiophysics.seas.harvard.edu/2010/08/425/#comments Sat, 28 Aug 2010 20:35:45 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=425 29. Vandeparre H, Gabriele S, Brau F, Gay C, Parker KK, Damman P. Hierarchical wrinkling patterns. Soft Matter. 2010;6:5751-5756.

]]> http://diseasebiophysics.seas.harvard.edu/2010/08/425/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2010/07/253/ http://diseasebiophysics.seas.harvard.edu/2010/07/253/#comments Thu, 08 Jul 2010 14:33:50 +0000 kkparker http://diseasebiophysics.seas.harvard.edu/2010/06/253/ 28. Bray MA, Adams WJ, Geisse NA, Feinberg AW, Sheehy SP, Parker KK. Nuclear morphology and deformation in engineered cardiac myocytes and tissues. Biomaterials. 2010;31:5143-5150.

]]> http://diseasebiophysics.seas.harvard.edu/2010/07/253/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2010/05/wp-contentuploads20100527_badrossamayetal_nanoletters_nanofiber-pdf/ http://diseasebiophysics.seas.harvard.edu/2010/05/wp-contentuploads20100527_badrossamayetal_nanoletters_nanofiber-pdf/#comments Wed, 26 May 2010 21:41:42 +0000 kkparker http://diseasebiophysics.seas.harvard.edu/?p=89 27. Badrossamay MR, McIlwee HA, Goss JA, Parker KK. Nanofiber assembly by rotary jet spinning. Nanoletters. 2010;10:2257-2261.

]]> http://diseasebiophysics.seas.harvard.edu/2010/05/wp-contentuploads20100527_badrossamayetal_nanoletters_nanofiber-pdf/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2010/05/surface-initiated-assembly-of-protein-nanofabrics/ http://diseasebiophysics.seas.harvard.edu/2010/05/surface-initiated-assembly-of-protein-nanofabrics/#comments Wed, 26 May 2010 17:45:39 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=71 26. Feinberg AW, Parker KK. Surface-initiated assembly of protein nanofabrics. Nanoletters. 2010;10:2184-2191.

]]> http://diseasebiophysics.seas.harvard.edu/2010/05/surface-initiated-assembly-of-protein-nanofabrics/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2010/05/a-multiscale-model-for-eccentric-and-concentric-cardiac-growth-through-sarcomerogenesis-2/ http://diseasebiophysics.seas.harvard.edu/2010/05/a-multiscale-model-for-eccentric-and-concentric-cardiac-growth-through-sarcomerogenesis-2/#comments Tue, 04 May 2010 16:24:26 +0000 lin http://diseasebiophysics.seas.harvard.edu/?p=158 25. Göktepe S, Abilez OJ, Parker KK, Kuhl E. A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis. J Theor Biol. 2010;265:433-442.

]]> http://diseasebiophysics.seas.harvard.edu/2010/05/a-multiscale-model-for-eccentric-and-concentric-cardiac-growth-through-sarcomerogenesis-2/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2010/05/biohybrid-thin-films-for-measuring-contractility-in-engineered-cardiovascular-muscle/ http://diseasebiophysics.seas.harvard.edu/2010/05/biohybrid-thin-films-for-measuring-contractility-in-engineered-cardiovascular-muscle/#comments Sun, 02 May 2010 02:14:58 +0000 chambers http://diseasebiophysics.seas.harvard.edu/2010/05/biohybrid-thin-films-for-measuring-contractility-in-engineered-cardiovascular-muscle/ 24. Alford PW, Feinberg AW, Sheehy SP, Parker KK. Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. Biomaterials. 2010;31:3613-3621.

]]> http://diseasebiophysics.seas.harvard.edu/2010/05/biohybrid-thin-films-for-measuring-contractility-in-engineered-cardiovascular-muscle/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2009/12/optimization-of-electroactive-hydrogel-actuators/ http://diseasebiophysics.seas.harvard.edu/2009/12/optimization-of-electroactive-hydrogel-actuators/#comments Thu, 24 Dec 2009 02:15:27 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=45 23. O’Grady M, Kuo P, Parker KK. Optimization of electroactive hydrogel actuators. ACS Appl Mater Interfaces. 2010;2:343-346.

]]> http://diseasebiophysics.seas.harvard.edu/2009/12/optimization-of-electroactive-hydrogel-actuators/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2009/10/generation-of-functional-ventricular-heart-muscle-from-mouse-ventricular-progenitor-cells/ http://diseasebiophysics.seas.harvard.edu/2009/10/generation-of-functional-ventricular-heart-muscle-from-mouse-ventricular-progenitor-cells/#comments Sat, 17 Oct 2009 02:15:49 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=47 22. Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, Shao Y, Wu SM, Parker KK, Chien KR. Generation of functional ventricular heart muscle from mouse ventricular progenitor Cells. Science. 2009;326(5951):426-429. [video download, 1.6 MB]

]]> http://diseasebiophysics.seas.harvard.edu/2009/10/generation-of-functional-ventricular-heart-muscle-from-mouse-ventricular-progenitor-cells/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2009/02/control-of-myocyte-remodeling-in-vitro-with-engineered-substrates/ http://diseasebiophysics.seas.harvard.edu/2009/02/control-of-myocyte-remodeling-in-vitro-with-engineered-substrates/#comments Sun, 01 Mar 2009 02:16:41 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=51 21. Geisse NA, Sheehy SP, Parker KK.Control of myocyte remodeling in vitro with engineered substrates. In Vitro Cell Dev Biol Anim. 2009;45:343-350.

]]> http://diseasebiophysics.seas.harvard.edu/2009/02/control-of-myocyte-remodeling-in-vitro-with-engineered-substrates/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2009/02/time-warped-comparison-of-gene-expression-in-adaptive-and-maladaptive-cardiac-hypertrophy/ http://diseasebiophysics.seas.harvard.edu/2009/02/time-warped-comparison-of-gene-expression-in-adaptive-and-maladaptive-cardiac-hypertrophy/#comments Thu, 19 Feb 2009 02:16:17 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=49 20. Sheehy SP, Huang S, Parker KK. Time-warped comparison of gene expression in adaptive and maladaptive cardiac hypertrophy. Circ Cardiovasc Genet. 2009;2:116-124.

]]> http://diseasebiophysics.seas.harvard.edu/2009/02/time-warped-comparison-of-gene-expression-in-adaptive-and-maladaptive-cardiac-hypertrophy/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2008/12/cardiogenesis-and-the-complex-biology-of-regenerative-cardiovascular-medicine/ http://diseasebiophysics.seas.harvard.edu/2008/12/cardiogenesis-and-the-complex-biology-of-regenerative-cardiovascular-medicine/#comments Sat, 06 Dec 2008 02:17:33 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=53 19. Bol M, Reese S, Parker KK, Kuhl K. Computational modeling of muscular thin films for cardiac repair. Computational Mechanics. 2009;43:535-544.

]]> http://diseasebiophysics.seas.harvard.edu/2008/12/cardiogenesis-and-the-complex-biology-of-regenerative-cardiovascular-medicine/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2008/09/computational-modeling-of-muscular-thin-films-for-cardiac-repair/ http://diseasebiophysics.seas.harvard.edu/2008/09/computational-modeling-of-muscular-thin-films-for-cardiac-repair/#comments Sun, 14 Sep 2008 02:18:20 +0000 chambers http://diseasebiophysics.seas.harvard.edu/?p=55 18. Chien KR, Domain IJ, Parker KK. Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science. 2008;322:1494-1497. Review.

]]> http://diseasebiophysics.seas.harvard.edu/2008/09/computational-modeling-of-muscular-thin-films-for-cardiac-repair/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2008/08/myofibrillar-architecture-in-engineered-cardiac-myocytes/ http://diseasebiophysics.seas.harvard.edu/2008/08/myofibrillar-architecture-in-engineered-cardiac-myocytes/#comments Fri, 15 Aug 2008 16:45:50 +0000 lin http://diseasebiophysics.seas.harvard.edu/?p=172 17. Parker KK, Tan J, Chen CS, Tung L. Myofibrillar architecture in engineered cardiac myocytes. 2008;103:340-342.

]]> http://diseasebiophysics.seas.harvard.edu/2008/08/myofibrillar-architecture-in-engineered-cardiac-myocytes/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2008/08/sarcomere-alignment-is-regulated-by-myocyte-shape/ http://diseasebiophysics.seas.harvard.edu/2008/08/sarcomere-alignment-is-regulated-by-myocyte-shape/#comments Fri, 01 Aug 2008 16:46:22 +0000 lin http://diseasebiophysics.seas.harvard.edu/?p=174 16. Bray MA, Sheehy SP, Parker KK. Sarcomere alignment is regulated by myocyte shape. Cell Motil Cytoskeleton. 2008;65:641-651.

]]> http://diseasebiophysics.seas.harvard.edu/2008/08/sarcomere-alignment-is-regulated-by-myocyte-shape/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2008/05/micropatterning-approaches-for-cardiac-biology/ http://diseasebiophysics.seas.harvard.edu/2008/05/micropatterning-approaches-for-cardiac-biology/#comments Thu, 15 May 2008 16:47:09 +0000 lin http://diseasebiophysics.seas.harvard.edu/?p=176 15. Geisse NA, Feinberg AW, Kuo P, Sheehy S, Bray MA, Parker KK. Micropatterning Approaches for Cardiac Biology. In: Khademhosseini A, Toner M, Borenstein JT, Takayama S, editors. Micro- and Nanoengineering of the Cell Microenvironment: Technologies and Applications. Boston: Artech House; 2008:341-357.

]]> http://diseasebiophysics.seas.harvard.edu/2008/05/micropatterning-approaches-for-cardiac-biology/feed/ 0 http://diseasebiophysics.seas.harvard.edu/2008/01/dynamic-control-of-protein-protein-interactions/ http://diseasebiophysics.seas.harvard.edu/2008/01/dynamic-control-of-protein-protein-interactions/#comments Tue, 01 Jan 2008 16:47:44 +0000 lin http://diseasebiophysics.seas.harvard.edu/?p=178 14. O’Grady ML, Parker KK. Dynamic control of protein-protein interactions. Langmuir. 2008;24:316-322.

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