Publications

144. Ziad AT, Zimmerman JF, Rao J, Sieiro D, McNamara HM, Cherrier T, Rodriguez-delaRosa A, Hick-Colin A, Bousson F, Fugier-Schmucker C, Marchianoi F, Habermanni B, Chala J, Nesmith AP, Gapon, Svetlana, Wagner E, Gupta VA, Bassel-Dubyk R, Olsonk EN, Cohen AE, Parker KK, and Pourquiea O. Prednisolone Rescues Duchenne Muscular Dystrophy Phenotypes in Human Pluripotent Stem Cell–Derived Skeletal Muscle in Vitro. PNAS. Jul 2021; 118(28) 1-12. doi: https://doi.org/10.1073/pnas.2022960118. PMID: 34260377.

143. Glieberman AL, Pope BD, Melton DA, Parker KK.Building Biomimetic Potency Tests for Islet Transplantation. Diabetes. Feb 2021; 70(2); 347-363. doi: 10.2337/db20-0297. PMID: 33472944.

142. Parker KK, Longobardi L, Sulicz A. Welcome to Biophysics Reviews, a big tent for the biophysics community. Biophysics Reviews. 14 Dec 2020; 1(1); 010401. DOI: 10.1063/5.0036408. [Editorial]

141. Pope BD, Warren CR, Dahl MO, Pizza CV, Henze DE, Sinatra NR, Gonzalez GM, Chang H, Liu Q, Gleiberman AL, Ferrier JP, Cowan CA, Parker KK. Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes in vitro. Lab on a Chip. 21 Sept 2020; https://doi.org/10.1039/D0LC00508H PMID: 33034335

140. Yadid M, Lind JU, Ardoña HAM, Sheehy SP, Dickinson LE, Eweje F, Bastings MCB, Pope B, O’Connor BB, Straubhaar JR, Budnik B, Kleber AG, Parker KK. Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip. Science Translational Medicine. 2020 Oct 14; 12(565); eaax8005. doi: 10.1126/scitranslmed.aax8005. PMID: 33055246. [Cover]

139. Ahn S, Chantre CO, Ardoña HAM, Gonzalez GM, Campbell PH, Parker KK.Biomimetic and estrogenic fibers promote tissue repair in mice and human skin via estrogen receptor β. Biomaterials. 2020 Oct; 255:120149. doi: 10.1016/j.biomaterials.2020.120149. Epub 2020 May 28. PMID: 32521331. Supplemental materials.

138. Aytac Z, Huang R, Vaze N, Xu T, Eitzer BD, Krol W, MacQueen LA, Chang H, Bousfield DW, Chan-Park MB, Ng KW, Parker KK, White JC, and Demokritou, P. Development of biodegradable and antimicrobial electrospun zein fibers for food packaging. ACS Sustainable Chem. Eng. 2020 Sep 21; 8(40):15354-15365. doi.org/10.1021/acssuschemeng.0c05917

137. Fioretta ES, Motta SE, Lintas Valentina, Loerakker S, Parker KK, Baaijens FPT, Falk V, Hoerstrup SP, and Emmert MY. Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity. Nat Rev Cardiol. 2020 Sep 9. doi: 10.1038/s41569-020-0422-8. Epub ahead of print. PMID: 32908285.

136. Gonzalez GM, Ward J, Song J, Swana K, Fossey SA, Palmer JL, Zhang FW, Lucian VM, Cera L, Zimmerman JF, Burpo FJ, and Parker KK. para-Aramid Fiber Sheets for Simultaneous Mechanical and Thermal Protection in Extreme Environments. Matter. 02 Sept 2020; 3(3):742-758. doi: 10.1016/j.matt.2020.06.001

135. Parker, KK. Some Data Is Hard To Get-Some Data You Have to Be Hard to Get. Matter. 02 Sept 2020; 3:623–627 doi: https://doi.org/10.1016/j.matt.2020.08.017

134. Herland A, Maoz BM, FitzGerald EA, Grevesse T, Vidoudez C, Sheehy SP, Budnik N, Dauth S, Mannix R, Budnik B, Parker KK, Ingber DE. Proteomic and Metabolomic Characterization of Human Neurovascular Unit Cells in Response to Methamphetamine. Advanced Biosystems. 2020 Sep; 4(9):e1900230. doi: 10.1002/adbi.201900230. Epub 2020 Aug 3. PMID: 32744807.

133. Cera L, Gonzalez GM, Liu Q, Choi S, Chantre CO, Lee J, Gabardi R, Choi MC, Shin K, Parker KK. A bioinspired and hierarchically structured shape-memory material. Nat. Mater. 2020 Aug 31. doi: 10.1038/s41563-020-0789-2. Epub ahead of print. PMID: 32868876.

132. Malladi S, Miranda-Nieves D, Leng L, Grainger SJ, Tarabanis C, Nesmith AP, Kosaraju R, Haller CA, Parker KK, Chaikof EL, Guenther A. Continuous Formation of Ultrathin, Strong Collagen Sheets with Tunable Anisotropy and Compaction. ACS Biomaterials Science & Engineering. 2020 Jul 13; 6(7):4236-4246. doi: 10.1021/acsbiomaterials.0c00321. Epub 2020 May 26. PMID: 32685675; PMCID: PMC7362332.

131. O’Connor BB, Pope B, Peters MM, Ris-Stalpers C, Parker KK. The role of extracellular matrix in normal and pathological pregnancy: Future applications of microphysiological systems in reproductive medicine. Experimental Biology and Medicine. 2020 Jul;245(13):1163-1174. doi: 10.1177/1535370220938741. Epub 2020 Jul 8. PMID: 32640894; PMCID: PMC7400725.

130. O’Connor BB, Grevesse T, Zimmerman JF, Ardoña HAM, Jimenez JA, Bitounis D, Demokritou P, Parker KK.Human brain microvascular endothelial cell pairs model tissue-level blood–brain barrier function. Integrative Biology. 2020 Apr 14; 2(3):64-79. doi: 10.1093/intbio/zyaa005 Epub 2020 Jan 05 PMID: 32195539; PMCID: PMC7155416.

129. Herland A, Maoz BM, Das D, Somayaji MR, Prantil-Baun R, Novak R, Cronce M, Huffstater T, Jeanty SSF, Ingram M, Chalkiadaki A, Chou DB, Marquez S, Delahanty A, Jalili-Firoozinezhad S, Sontheimer-Phelps A, Swenor B, Levy O, Parker KK, Przekwas A, Ingber DE. Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips. Nature Biomedical Engineering. 2020 Apr;4(4):421-436. doi: 10.1038/s41551-019-0498-9. Epub 2020 Jan 27. PMID: 31988459.

128. Novak R, Ingram M, Marquez S, Das D, Delahanty A, Herland A, Maoz BM, Jeanty SSF, Somayaji MR, Burt M, Calamari E, Chalkiadaki A, Cho A, Choe Y, Chou DB, Cronce M, Dauth S, Divic T, Fernandez-Alcon J, Ferrante T, Ferrier J, FitzGerald EA, Fleming R, Jalili-Firoozinezhad S, Grevesse T, Goss JA, Hamkins-Indik T, Henry O, Hinojosa C, Huffstater T, Jang KJ, Kujala V, Leng L, Mannix R, Milton Y, Nawroth J, Nestor BA, Ng CF, O’Connor B, Park TE, Sanchez H, Sliz J, Sontheimer-Phelps A, Swenor B, Thompson G, Touloumes GJ, Tranchemontagne Z, Wen N, Yadid M, Bahinski A, Hamilton GA, Levner D, Levy O, Przekwas A, Prantil-Baun R, Parker KK, Ingber DE. Robotic fluidic coupling and interrogation of multiple vascularied organ chips. Nature Biomedical Engineering. 2020 Apr;4(4):407-420. doi: 10.1038/s41551-019-0497-x. Epub 2020 Jan 27. PMID: 31988458.

127. Garbern JC, Helman A, Sereda R, Sarikhani M, Ahmed A, Escalante GO, Ogurlu R, Kim SL, Zimmerman JF, Cho A, MacQueen LM, Bezzerides VJ, Parker KK, Melton DA, Lee RT.Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells via p53-Induced Quiescence. Circulation. 2020 Jan 28; 141(4):285-300. doi: 10.1161/CIRCULATIONAHA.119.044205. Epub 2019 Nov 11. PMID: 31707831; PMCID: PMC7009740.

126. Touloumes GJ, Ardoña HAM, Casalino EK, Zimmerman JF, Chantre CO, Bitounis D, Demokritou P, Parker KK. Mapping 2D-and 3D-distributions of metal/metal oxide nanoparticles within cleared human ex vivo skin tissues. Nanoimpact. 2020 Jan 13;17: 100208. doi: 10.1016/j.impact.2020.100208. NIHMS 1556883.

125. Chantre CO, Gonzalez GM, Ahn S, Cera L, Campbell PH, Hoerstrup SP, Parker KK. Porous Biomimetic Hyaluronic Acid and Extracellular Matrix Protein Nanofiber Scaffolds for Accelerated Cutaneous Tissue Repair. ACS Applied Materials and Interfaces. 2019 Dec 11; 11(49):45498-45510. doi: 10.1021/acsami.9b17322. Epub 2019 Nov 22. PMID: 31755704.

124. MacQueen LM, Alver CG, Chantre CO, Ahn S, Cera L, Gonzalez GM, O’Connor BB, Drennan DJ, Peters MM, Motta SE, Zimmerman JF, Parker KK. Muscle tissue engineering in fibrous gelatin: implications for meat analogs. npj Science of Food. 2019 Oct 21; 3:20. doi: 10.1038/s41538-019-0054-8. PMID: 31646181; PMCID: PMC6803664.

123. Eweje F, Ardoña HAM, Zimmerman JF, O’Connor BB, Ahn S, Grevesse T, Rivera KN, Demokritou P, Parker KK. Quantifying the effects of engineered nanomaterials on endothelial cell architecture and vascular barrier integrity using a cell pair model. Nanoscale. 2019 Oct 3; 11(38): 17878-17893. doi: 10.1039/c9nr04981a Epub 2019 Sept 24 PMID: 31553035; PMCID: PMC6779057.

122. Ahn S, Ardoña HAM, Campbell PH, Gonzalez GM, Parker KK. Alfalfa Nanofibers for Dermal Wound Healing. ACS Applied Materials & Interfaces. 2019 Sep 18; 11(37):33535-33547. doi: 10.1021/acsami.9b07626. Epub 2019 Aug 9. PMID: 31369233.

121. Glieberman AL, Pope BD, Zimmerman JF, Liu Q, Ferrier JP, Kenty JHR, Schrell AM, Mukhitov N, Shores KL, Tepole AB, Melton DA, Roper MG, Parker KK. Synchronized Stimulation and Continuous Insulin Sensing in a Microfluidic Human Islet on a Chip Designed for Scalable Manufacturing Lab on a Chip. 2019 Sep 10; 19(18):2993-3010. doi: 10.1039/c9lc00253g. Epub 2019 Aug 29 PMID: 31464325; PMCID: PMC6814249.

120. Sinatra NR, Teeple CB, Vogt DM, Parker KK, Gruber DG, Wood RJ. Ultragentle Manipulatoin of Delicate Structures Using a Soft Robotic Gripper. Science Robotics 2019 Aug 28; 4(33):eaax5425. doi: 10.1126/scirobotics.aax5425. Epub 21 Aug 2019 PMID: 33137785.

119. Park SJ, Zhang D, Qi Y, Li Y, Lee KY, Bezzerides VJ, Yang P, Xia S, Kim SL, Liu X, Lu F, Pasqualini FS, Campbell PH, Geva J, Roberts A, Kleber AG, Abrams DJ, Pu WT, Parker KK. Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. Circulation. 2019 Jul 30; 140(5):390-404. doi: 10.1161/CIRCULATIONAHA.119.039711. Epub 2019 Jul 17. PMID: 31311300; PMCID: PMC6750809.

118. Chantre CO, Hoerstrup SP, Parker KK. Engineering biomimetic and instructive materials for wound healing and regeneration. Current Opinion in Biomedical Engineering. 2019 May 9; doi: 10.1016/j.cobme.2019.04.004 Epub 2019 May 9

117. Soum V, Park S, Brilian AI, Kim Y, Ryu MY, Brazell T, Burpo FJ, Parker KK, Kwon OS, Shin K. Inkjet-Printed Carbon Nanotubes for Fabricating a Spoof Fingerprint on Paper. ACS Omega. 2019 May 16; 4(5):8626-31. doi: 10.1021/acsomega.9b00936. PMID: 31459951; PMCID: PMC6648154.

116. Zimmerman JF, Ardoña HAM, Pyrgiotakis G, Dong J, Moudgil B, Demokritou P, Parker KK. Scatter Enhanced Phase Contrast Microscopy for Discriminating Mechanisms of Active Nanoparticle Transport in Living Cells. Nanoletters. . 2019 Feb 13; 19(2):793-804. doi: 10.1021/acs.nanolett.8b03903. Epub 2019 Jan 23. PMID: 30616354; PMCID: PMC6588408.

115. Parker KK. Designer Assays for Your Sick, Subdivided Heart. Cell. 2019 Feb 7; 176(4):684-685. doi: 10.1016/j.cell.2019.01.028. Epub 2019 Jan 28 PMID: 30735631.

114. MacQueen LA, Sheehy SP, Chantre CO, Zimmerman JF, Pasqualini FS, Liu X, Goss JA, Campbell PH, Gonzalez GM, Park SJ, Capulli AK, Ferrier JP, Kosar TF, Mahadevan L, Pu WT, Parker KK. A tissue-engineered scale model of the heart ventricle. Nat. Biomed. Eng. 2018 Dec; 2(12):930-941. doi: 10.1038/s41551-018-0271-5. Epub 2018 Jul 23. PMID: 31015723; PMCID: PMC6774355.

113. Liu Q, Parker KK. A viscoelastic beam theory of polymer jets with application to rotary jet spinning. Extreme Mechanics Letters. 2018 Nov; 25. doi: 10.1016/j.eml.2018.10.005

112. Maoz BM, Herland A, FitzGerald EA, Grevesse T, Vidoudez C, Pacheco AR, Sheehy SP, Park TE, Dauth S, Mannix R, Budnik N, Shores K, Cho A, Nawroth JC, Segrè D, Budnik B, Ingber DE, Parker KK. A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. Nat. Biotechnol. 2018 Oct; 36(9); 865-874. doi: 10.1038/nbt.4226. Epub 2018 Aug 20. PMID: 30125269.

111. Ahn S, Ardoña HAM, Lind JU, Eweje F, Kim SL, Gonzalez GM, Liu Q, Zimmerman JF, Pyrgiotakis G, Zhang Z, Beltran-Huarac J, Carpinone P, Moudgil BM, Demokritou P, Parker KK. Mussel-Inspired 3D Fiber Scaffolds for Heart-on-a-Chip Toxicity Studies of Engineered Nanomaterials. Anal Bioanal Chem. 2018 Sep; 410(24); 6141-6154. doi: 10.1007/s00216-018-1106-7. Epub 2018 May 10. PMID: 29744562; PMCID: PMC6230313.

110. Sinatra NR, Ranzani T, Vlassak JJ, Parker KK, Wood RJ. Nanofiber-reinforced soft fluidic micro-actuators. J. Micromech. Microeng. 2018 Aug 1; 28(8): 84002. doi: 10.1088/1361-6439/aab373

109. Lee KY, Park S-J, Lee KA, Kim S-H, Kim H, Meroz Y, Mahadevan L, Jung K-H, Ahn TK, Parker KK, Shin K. Photosynthetic Artificial Organelles Sustain and Control ATP-Dependent Reactions in a Protocellular System. Nat Biotechnol. 2018 Jul; 36(6); 530-535. doi: 10.1038/nbt.4140. Epub 2018 May 28. PMID: 29806849.

108. Chantre CO, Campbell PH, Golecki HM, Buganza AT, Capulli AK, Deravi LF, Dauth S, Sheehy SP, Paten JA, Gledhill K, Doucet YS, Abaci HE, Ahn S, Pope BD, Ruberti JW, Hoerstrup SP, Christiano AM, Parker KK Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model Biomaterials. 2018 Jun; 166:96-108. doi: 10.1016/j.biomaterials.2018.03.006. Epub 2018 Mar 5. PMID: 29549768; PMCID: PMC6859458.

107. Ahn S, Chantre CO, Gannon AR, Lind JU, Campbell PH, Grevesse T, O’Connor BB, Parker KK Soy Protein/Cellulose Nanofiber Scaffolds Mimicking Skin Extracellular Matrix for Enhanced Wound Healing Advanced Healthcare Materials. 2018 May 9; 7(9): e1701175. doi: 10.1002/adhm.201701175. Epub 2018 Jan 23. PMID: 29359866; PMCID: PMC6481294.

106. Pasqualini FS, Agarwal A, O’Connor BB, Liu Q, Sheehy SP, Parker KK. Traction force microscopy of engineered cardiac tissues. PLOS One. 2018 Mar 28;13(3):e0194706. doi: 10.1371/journal.pone.0194706. PMID: 29590169; PMCID: PMC5874032.

105. Seungkuk Ahn, Keel Yong Lee, Kwanwoo Shin, Parker KK Formation of Multi-Component Extracellular Matrix Protein Fibers Scientific Reports. 2018 Jan 30; 8(1):1913. doi: 10.1038/s41598-018-20371-8. PMID: 29382927; PMCID: PMC5790006.

104. Janna C Nawroth, Lisa L Scudder, Ryan T Halvorson, Jason Tresback, John P Ferrier Jr, Sean P Sheehy, Alex Cho, Suraj Kannan, Ilona Sunyovszki, Josue A Goss, Patrick H Campbell and Parker KK Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications Biofabrication. 2018 Jan 16; 10(2); 25004. doi: 10.1088/1758-5090/aa96de. PMID: 29337695; PMCID: PMC6221195.

103. Yuan H, Marzban B, Parker KK Myofibrils in Cardiomyocytes Tend to Assemble Along the Maximal Principle Stress Directions. J Biomech Eng. 2017 Dec 1; 139(12); 1210101-8. doi: 10.1115/1.4037795. Epub 2017 Aug 31 PMID: 28857113; PMCID: PMC5691293.

102. Ricotti L, Trimmer B, Feinberg AW, Raman R, Parker KK, Bashir R, Sitti M, Martel S, Dario P, Menciassi A. Biohybrid actuators for robotics: A review of devices actuated by living cells. Science. 2017 Nov 29:eaaq0495. doi: 10.1126/scirobotics.aaq0495. Epub 2017 Nov 29. PMID: 33157905.

101. Sheehy SP, Grosberg A, Qin P, Behm DJ, Ferrier JP, Eagleson MA, Nesmith AP, Krull D, Falls JG, Campbell PH, McCain ML, Willette RN, Hu E, Parker KK. Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes. Exp Biol Med (Maywood). 2017 Nov; 242(17); 1643-1656. doi: 10.1177/1535370217701006. Epub 2017 Mar 26. PMID: 28343439; PMCID: PMC5786366.

100. Johan U. Lind, Moran Yadid, Ian Perkins, Blakely B. O’Connor, Feyisayo Eweje, Christophe O. Chantre, Matthew A. Hemphill, Hongyan Yuan, Patrick H. Campbell, Joost J. Vlassak and Parker KK Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening. Lab Chip. 2017 Oct 25; 17(21); 3692-3703. doi: 10.1039/c7lc00740j. Epub 2017 Oct 4 PMID: 28976521; PMCID: PMC5810940.

99. Generali M, Kehl D, Capulli AK, Parker KK, Hoerstrup SP, Weber B. Comparative analysis of poly-glycolic acid-based hybrid polymer starter matrices for in vitro tissue engineering. Colloids Surf B Biointerfaces. 2017 Oct 1; 158; 203-212. doi: 10.1016/j.colsurfb.2017.06.046. Epub 2017 Jul 1. PMID: 28697435.

98. Ko H, Deravi LF, Park SJ, Jang J, Lee T, Kang C, Lee JS, Parker KK, Shin K. Fabrication of Millimeter-Long Carbon Tubular Nanostructures Using the Self-Rolling Process Inherent in Elastic Protein Layers. Adv Mater. 2017 Aug 18; 29(31). doi: 10.1002/adma.201701732. Epub 2017 Jun 19. PMID: 28627043.

97. Maoz BM, Herland A, Henry OYF, Leineweber WD, Yadid M, Doyle J, Mannix R, Kujala VJ, Fitzgerald EA, Parker KK, Ingber DE. Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities. Lab Chip. 2017 Jun 27;17(13):2294-2302. doi: 10.1039/c7lc00412e. Epub 2017 June 7 PMID: 28608907.

96. Capulli AK, Emmert MY, Pasqualini FS, Kehl D, Caliskan E, Lind JU, Sheehy SP, Park SJ, Ahn S, Weber B, Goss JA, Hoerstrup SP, Parker KK. JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement. Biomaterials. 2017 Jul; 133; 229-241. doi: 10.1016/j.biomaterials.2017.04.033. Epub 2017 Apr 18. PMID: 28445803; PMCID: PMC5526340.

95. Emmert MY, Wolint P, Jakab A, Sheehy SP, Pasqualini FS, Nguyen TD, Hilbe M, Seifert B, Weber B, Brokopp CE, Macejovska D, Caliskan E, von Eckardstein A, Schwartlander R, Vogel V, Falk V, Parker KK, Gyöngyösi M, Hoerstrup SP. Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction – From cardioprotection to functional repair in a translational pig infarction model.
Biomaterials. 2017 Apr;122:48-62. 10.1016/j.biomaterials.2016.11.029. Epub 2016 Nov 23. PMID: 28107664.

94. Dauth S, Maoz BM, Sheehy SP, Hemphill MA, Murty T, Macedonia MK, Greer AM, Budnik B, Parker KK. Neurons derived from different brain regions are inherently different in vitro: A novel multiregional brain-on-a-chip. Journal of Neurophysiology. 2017 Mar 1; 117(3); 1320-1341. doi: 10.1152/jn.00575.2016. Epub 2016 Dec 28. PMID: 28031399; PMCID: PMC5350271.

93. Lind JU, Busbee TA, Valentine AD, Pasqualini FS, Yuan H, Yadid M, Park SJ, Kotikian A, Nesmith AP, Campbell PH, Vlassak JJ, Lewis JA, Parker KK. Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing. Nature Materials. 2017 Mar; 16(3); 303-308. doi: 10.1038/nmat4782. Epub 2016 Oct 24. PMID: 27775708; PMCID: PMC5321777.

92. Deravi LF, Sinatra NR, Chantre CO, Nesmith AP, Yuan H, Deravi SK, Goss JA, MacQueen LA, Badrossamy MR, Gonzalez GM, Phillips MD, Parker KKDesign and fabrication of fibrous nanomaterials using pull spinning. Macromolecular Materials and Engineering. 17 January 2017; 302(3):1600404. doi: 10.1002/mame.201600404

91. Pasqualini FS, Emmert MY, Parker KK, Hoerstrup SP.  Organ Chips: Quality Assurance Systems in Regenerative Medicine.  Clin Pharmacol Ther. . 2017 Jan; 101(1); 31-34. doi: 10.1002/cpt.527. Epub 2016 Nov 21. PMID: 27709615; PMCID: PMC5191973.

90. Pasqualini FS, Nesmith AP, Horton RE, Sheehy SP, Parker KK.  Mechanotransduction and Metabolism in Cardiomyocyte Microdomains.  BioMed Research International. 2016; 2016:4081638. doi: 10.1155/2016/4081638. Epub 2016 Dec 4. PMID: 28044126; PMCID: PMC5164897.

89.  Benam KH, Novak R, Nawroth J, Hirano-Kobayashi M, Ferrante TC, Choe Y, Prantil-Baun R, Weaver JC, Bahinski A, Parker KK, Ingber DE. Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip. Cell Systems. 2016 Nov 23; 3(5); 456-466.e4. doi: 10.1016/j.cels.2016.10.003. Epub 2016 Oct 27. PMID: 27894999.

88. Nesmith, AP, Wagner MA, Pasqualini FS, O’Connor BB, Pincus MJ, August PR, Parker KK. A human in vitro model of Duchenne muscular dystrophy muscle formation and contractility.  The Journal of Cell Biology. 2016 Oct 10; 215(1); 47-56. doi: 10.1083/jcb.201603111. Epub 2016 Oct 3. PMID: 27697929; PMCID: PMC5057287.

87. Gonzalez GM, MacQueen LA, Lind JU, Fitzgibbons SA, Chantre CO, Huggler I, Golecki HM, Goss JA, Parker KK. Production of synthetic, para-aramid and biopolymer nanofibers by immersion rotary jet-spinning. Macromolecular Materials and Engineering. 2017 Jan 12; 302(1); 1600365. doi: 10.1002/mame.201600365 Epub 2016 Oct 7

86. Chal J, Tanoury ZA, Hestin M, Gobert B, Aivio S,Hick A,Cherrier T, Nesmith AP,  Parker KK, Pourquié O. Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro. Nature Protocols. 2016 Oct; 11(10); 1833-50. doi: 10.1038/nprot.2016.110. Epub 2016 Sep 1. PMID: 27583644.

85. Pope BD, Warren CR, Parker KK, Cowan, CA. Microenvironmental control of adipocyte fate and function. Trends in Cell Biology. 2016 Oct; 26(10); 745-55. doi: 10.1016/j.tcb.2016.05.005. Epub 2016 Jun 4. PMID: 27268909; PMCID: PMC6788628.

84.  Capulli AK, MacQueen LA, O’Connor BB, Dauth S, Parker KK. Acute pergolide exposure stiffens engineered valve interstitial cell tissues and reduced contractility in vitro. Cardiovascular Pathology. 2016 Jul-Aug; 25(4); 316-324. doi: 10.1016/j.carpath.2016.04.004. Epub 2016 Apr 25. PMID: 27174867; PMCID: PMC4902741.

83. Park SJ, Gazzola M, Park KS, Park S, DiSanto V, Blevins EL, Lind JU, Campbell PH, Dauth S, Capulli AK, Pasqualini FS, Ahn S, Cho A, Yuan H, Maoz BM, Vijaykumar R, Choi JW, Deisseroth K, Lauder GV, Mahadevan L, Parker KK. Phototactic guidance of a tissue-engineered soft-robotic ray. Science. 2016 July 8; 353(6295); 158-162. doi: 10.1126/science.aaf4292. PMID: 27387948; PMCID: PMC5526330.

82.  Kujala VJ, Pasqualini FS, Goss JA, Nawroth JC, Parker KKLaminar ventricular myocardium on a microelectrode array-based chip. Journal of Materials Chemistry B. 2016 May 28; 4(20):3534-3543. doi: 10.1039/c6tb00324a. Epub 2016 Apr 21. PMID: 32263387.

81.Dauth S, Grevesse T, Pantazopoulos H, Campbell PH, Maoz, BM, Berretta S and Parker KK. Extracellular matrix protein expression is brain region dependent. J Comp Neurol. 2016 May 1; 524(7); 1309-36. doi: 10.1002/cne.23965. Epub 2016 Feb 1. PMID: 26780384.

80. Aratyn-Schaus Y, Pasqualini FS, Yuan H, McCain ML, Ye GJ, Sheehy SP, Campbell PH, Parker KKCoupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy. J Cell Biol. 2016 Feb 8. doi: 10.1083/jcb.201508026

79.  Horton RE, Yadid M, McCain, ML, Sheehy SP, Pasqualini FS, Park SJ, Cho A, Campbell P, Parker KK. Angiotensin II Induced Cardiac Dysfunction on a Chip. PLos ONE. 2016 Jan 25; 1(1):e0146415. doi: 10.1371/journal.pone.0146415. PMID: 26808388; PMCID: PMC4725954.

78.  Capulli AK, MacQueen LA, Sheehy SP, Parker KK.  Fibrous scaffolds for building hearts and heart parts.  Adv. drug delivery reviews. 2016 Jan 15; 96:83-102. doi: 10.1016/j.addr.2015.11.020. Epub 2015 Dec 4. PMID: 26656602; PMCID: PMC4807693.

77. Lee H, Adams WJ, Alford PW, McCain ML, Feinberg AW, Sheehy SP, Goss JA, Parker KK. Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes. Exp Biol Med (Maywood). 2015 Nov; 240(11):1543-54. doi: 10.1177/1535370215583799. Epub 2015 Apr 23. PMID: 25908635; PMCID: PMC4778402.

76. Maia PD, Hemphill MA, Zehnder B, Zhang C, Parker KK, Kutz JN.  Diagnostic tools for evaluating the impact of Focal Axonal Swellings arising in neurodegenerative diseases and/or traumatic brain injury. J Neurosci Methods. 2015 Sept 30;253:233-243. doi: 10.1016/j.jneumeth.2015.06.022. Epub 2015 Jul 16. PMID: 26188255.

75.  Ahn S, Deravi LF, Park SJ, Dabiri BE, Kim JS, Parker KK, Shin K.Self-organizing large-scale extracellular-matrix protein networks. Adv Mater. 2015 May 13;27(18):2838-45. doi: 10.1002/adma.201405556. Epub 2015 Mar 31. PMID: 25833069.

74. Drew NK, Eagleson MA, Baldo DB Jr, Parker KK, Grosberg A. Metrics for assessing cytoskeletal orientational correlations and consistency. PLoS Comput Biol. 2015 Apr 7;11(4):e1004190. doi: 10.1371/journal.pcbi.1004190. PMID: 25849553; PMCID: PMC4388480.

73. Grevesse T, Dabiri BE, Parker KK, Gabriele S. Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury. Sci Rep. 2015 Mar 30;5:9475. doi: 10.1038/srep09475. PMID: 25820512; PMCID: PMC4377573.

72. Hemphill MA, Dauth S, Yu CJ, Dabiri BE, Parker KK. Traumatic Brain Injury and the Neuronal Microenvironment: A Potential Role for Neuropathological Mechanotransduction. Neuron. 2015 Mar 18;85(6):1177-1192. doi: 10.1016/j.neuron.2015.02.041. PMID: 25789754.

71. Pasqualini FS, Sheehy SP, Agarwal A, Aratyn-Schaus Y, Parker KK. Structural Phenotyping of Stem Cell Derived Cardiomyocytes. Stem Cell Reports. 2015 Mar 10;4(3):340-7. doi: 10.1016/j.stemcr.2015.01.020. Epub 2015 Feb 26. PMID: 25733020; PMCID: PMC4375945.
Downloadable Content: ImageJ Scripts, Dataset for differentiated, immature, and mature cardiomyocytes.

70. Benam KH, Dauth S, Hassell B, Herland A, Jain A, Jang KJ, Karalis K, Kim HJ, MacQueen L, Mahmoodian R, Musah S, Torisawa YS, van der Meer AD, Villenave R, Yadid M, Parker KK, Ingber DE. Engineered in vitro disease models. Annu Rev Pathol. 2015;10:195-262. doi: 10.1146/annurev-pathol-012414-040418. PMID: 25621660.

69. Golecki HM, Yuan H, Glavin C, Potter B, Badrossamay MR, Goss JA, Phillips MD, Parker KK. Effect of solvent evaporation on fiber morphology in rotary jet spinning. Langmuir. 2014 Nov 11;30(44):13369-74. doi: 10.1021/la5023104. Epub 2014 Oct 29. PMID: 25353398; PMCID: PMC4901524.

68. Nesmith AP, Agarwal A, McCain ML, Parker KK. Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation. Lab Chip. 2014 Oct21; 14(20):3925-3936. doi: 10.1039/c4lc00688g. PMID: 25093641; PMCID: PMC4167568.

67. Capulli AK, Tian K, Mehandru N, Bukhta A,, Choudhury SF, Suchyta M and Parker KK. Approaching the in vitro clinical trial: engineering organs on chips. Lab Chip. 2014 Sep 7;14(17):3181-6. doi: 10.1039/c4lc00276h. PMID: 24828385; PMCID: PMC4117800

66. Ye GJ, Nesmith AP, Parker KK.The role of mechanotransduction on vascular smooth muscle myocytes cytoskeleton and contractile function. Anat Rec (Hoboken). 2014 Sep;297(9):1758-69. doi: 10.1002/ar.22983. Erratum in: Anat Rec (Hoboken). 2015 Mar;298(3):637. PMID: 25125187; PMCID: PMC4863956.

65. McCain ML, Agarwal A, Nesmith HW, Nesmith AP, Parker KK. Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues Biomaterials. 2014 Jul;35(21):5462-71. doi: 10.1016/j.biomaterials.2014.03.052. Epub 2014 Apr 14. PMID: 24731714; PMCID: PMC4057039.

64. Mosadegh B, Dabiri BE, Lockett MR, Derda R, Campbell P, Parker KK and Whitesides GM. Three-Dimensional Paper-Based Model for Cardiac Ischemia. Adv. Healthc. Mater. 2014 Jul; 3(7):1036-43. doi: 10.1002/adhm.201300575. Epub 2014 Feb 12. PMID: 24574054; PMCID: PMC4107065.

63. McCain ML, Yuan H, Pasqualini FS, Campbell PH, Parker KK. Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. Am J Physiol Heart Circ Physiol. Jun 2014 1; 306(11):H1525-H1539. doi: 10.1152/ajpheart.00799.2013. Epub 2014 Mar 28. PMID: 24682394; PMCID: PMC4042196.

62. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun;20(6):616-23. doi: 10.1038/nm.3545. Epub 2014 May 11. PMID: 24813252; PMCID: PMC4172922.

61. Sheehy SP, Pasqualini F, Grosberg A, Park SJ, Yvonne Aratyn-Schaus Y, Parker KK. Quality Metrics for Stem Cell-Derived Cardiac Myocytes. Stem Cell Reports. 2014 Mar 6;2(3):282-294. doi: 10.1016/j.stemcr.2014.01.015. PMID: 24672752; PMCID: PMC3964283.

60. Badrossamay MR, Balachandran K, Capulli AK, Golecki HM, Agarwal A, Goss JA, Kim H, Shin K, Parker KK. Engineering hybrid polymer-protein super-aligned nanofibers via rotary jet spinning. Biomaterials. 2014 Mar;35(10):3188-97. doi: 10.1016/j.biomaterials.2013.12.072. Epub 2014 Jan 20. PMID: 24456606.

59. Ye GJC, Aratyn-Schaus Y, Nesmith AP, Pasqualini FS, Alford, PW, and Parker KK. The contractile strength of vascular smooth muscle myocytes is shape dependent. Integr. Biol. 2014 Feb; 6(2):152-163. doi: 10.1039/c3ib40230d. PMID: 24406783.

58. Deravi LF, Magyar AP, Sheehy SP, Bell GRR, Mäthger LM, Senfta SL, Wardill TJ, Lane WS, Kuzirian AM, Hanlon RT, Hu EL, and Parker KK. The structure–function relationships of a natural nanoscale photonic device in cuttlefish chromatophores. J. R. Soc. Interface. 2014 Jan 29; 11(93):20130942. doi: 10.1098/rsif.2013.0942. PMID: 24478280; PMCID: PMC3928930.

57. Nawroth JC, Parker KK. Design standards for engineered tissues. Biotechnol Adv. 2013 Sep-Oct;31(5):632-7. doi: 10.1016/j.biotechadv.2012.12.005. Epub 2012 Dec 23. PMID: 23267860; PMCID: PMC3644329.

56. Agarwal A, Goss JA, Cho A, McCain ML and Parker KK. Microfluidic heart on a chip for higher throughput pharmacological studies. Lab on a Chip. 2013; 13(18): 3599–608

55.  Agarwal A, Farouz Y, Nesmith AP, Deravi LF, McCain ML, Parker KK. Micropatterning Alginate Substrates for In Vitro Cardiovascular Muscle on a Chip.. Adv. Funct. Mater. Adv. Funct. Mater. 2013 Aug 12; 23(30):3738–46. doi: 10.1002/adfm.201203319. PMID: 26213529; PMCID: PMC4511503.

54. McCain ML, Sheehy SP, Grosberg A, Goss JA, and Parker KK.
Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. PNAS. 2013 May 11; 110(24):9770-9775. doi: 10.1073/pnas.1304913110. Epub 2013 May 28. PMID: 23716679; PMCID: PMC3683774.

53. Deravi LF, Golecki HM, and Parker KK. Protein-Based Textiles: Bio-Inspired and Bio-Derived Materials for Medical and Non-Medical Applications. J. Chem. Biol. Interfaces. 2013 Apr; 1(1):25-34. doi: 10.1166/jcbi.2013.1009

52.  Kuo P, Lee H, Bray MA, Geisse NA, Huang YT, Adams WJ, Sheehy SP, Parker KK. Myocyte shape regulates lateral registry of sarcomeres and contractility. Am. J. Pathol. 2012 Dec; 181(6):2030-7. doi: 10.1016/j.ajpath.2012.08.045. PMID: 23159216; PMCID: PMC3509763.

51. Deravi LF, Su T, Paten JA, Ruberti, JW, Bertoldi K, Parker KK. Differential Contributions of Conformation Extension and Domain Unfolding to Properties of Fibronectin Nanotexiles. Nano Letters. 2012 Nov 14; 12(11):5587–5592. doi: 10.1021/nl302643g. Epub 2012 Oct 8. PMID: 23043581.

50. Sheehy SP, Grosberg A, Parker KK. The contribution of cellular mechanotransduction to cardiomyocyte form and function. Biomech Model Mechanobiol. 2012 Nov; 11(8): 1227-1239. doi: 10.1007/s10237-012-0419-2. Epub 2012 Jul 7. PMID: 22772714; PMCID: PMC3786397.

49. Dabiri BE, Lee H, Parker KK. A potential role for integrin signaling in mechanoelectrical feedback. Prog Biophys Mol Biol. 2012 Oct-Nov; 110(43864): 196–203. doi: 10.1016/j.pbiomolbio.2012.07.002. Epub 2012 Jul 20. PMID: 22819851; PMCID: PMC4807692.

48. Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A, Dabiri JO, Parker KK. A tissue-engineered jellyfish with biomimetic propulsion. Nat Biotechnol. 2012 Aug 30;30(8);792-797. doi: 10.1038/nbt.2269. PMID: 22820316; PMCID: PMC4026938.[Cover]

47. Feinberg AW, Alford PW, Jin H, Ripplinger CM, Werdich AA, Sheehy SP, Grosberg A, Parker KK. Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture. Biomaterials. 2012 Aug;33(23):5732-5741. doi: 10.1016/j.biomaterials.2012.04.043. Epub 2012 May 15. PMID: 22594976; PMCID: PMC4026933.

46. McCain ML, Lee H, Aratyn-Schaus Y, Kléber AG, Parker KK. Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle. PNAS. 2012 Jun 19;109(25):9881-9886. doi: 10.1073/pnas.1203007109. Epub 2012 Jun 6. PMID: 22675119; PMCID: PMC3382528.

45. Grosberg A, Nesmith AP, Goss JA, Brigham MD, McCain ML, Parker KK. Muscle on a chip: In vitro contractility assays for smooth and striated muscle. J Pharmacol Toxicol Methods. 2012 May-Jun;65(3):126-135.doi: 10.1016/j.vascn.2012.04.001. Epub 2012 Apr 12. PMID: 22521339; PMCID: PMC4184427.

44. Beauchamp P, Desplantez T, McCain ML, Li W, Asimaki A, Rigoli G, Parker KK, Saffitz JE, Kleber AG. Electrical Coupling and Propagation in Engineered Ventricular Myocardium With Heterogeneous Expression of Connexin43. Circ Res. 2012 May 25;110(11):1445-1453. doi: 10.1161/CIRCRESAHA.111.259705. Epub 2012 Apr 19. PMID: 22518032; PMCID: PMC3381798.

43. Desplantez T, McCain ML, Beauchamp P, Rigoli G, Rothen-Rutishauser B, Parker KK, Kleber AG. Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current. Cardiovasc Res. 2012 Apr 1;94(1):58-65. doi: 10.1093/cvr/cvs025. Epub 2012 Jan 27. PMID: 22287588; PMCID: PMC3307380.

42. Shim J, Grosberg A, Nawroth JC, Parker KK, Bertoldi K. Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior. J. Biomech. 2012 Mar 15;45(5):832-841. doi: 10.1016/j.jbiomech.2011.11.024. Epub 2012 Jan 10. PMID: 22236531; PMCID: PMC3294204.

41. McCain ML, Desplantez T, Geisse NA, Rothen-Rutishauser B, Oberer H, Parker KK, Kleber AG. Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance. Am J Physiol Heart Circ Physiol. 2012 Jan;302(2):H443-H450. doi: 10.1152/ajpheart.01218.2010. Epub 2011 Nov 11. PMID: 22081700; PMCID: PMC3339855.

40. Sheehy SP, Parker KK. The Role of Mechanical Forces in Guiding Tissue Differentiation. In: Bernstein H, editor. Tissue Engineering in Regenerative Medicine. Springer; 2011:77-97.

39. Grosberg A, Alford PW, McCain ML, Parker KK. Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip. Lab Chip. 2011 Dec 21;11(24):4165-4173. doi: 10.1039/c1lc20557a. Epub 2011 Nov 10. PMID: 22072288; PMCID: PMC4038963.

38. Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA, Parker KK. Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. PNAS. 2011 Dec 13;108(50):19943-19948. doi: 10.1073/pnas.1106954108. Epub 2011 Nov 28. PMID: 22123981; PMCID: PMC3250145.

37. Mellado P, McIlwee HA, Badrossamay MR, Goss JA, Mahadevan L, Parker KK. A simple model for nanofiber formation by rotary jet-spinning. Appl Phys Lett. 2011 Nov 15;99(20):203107. doi: 10.1063/1.3662015.

36. Alford PW, Nesmith AP, Seywerd, JN, Grosberg A, Parker KK. Vascular smooth muscle contractility depends on cell shape. Integr. Biol. 2011 Nov;3(11):1063-1070. doi: 10.1039/c1ib00061f. Epub 2011 Oct 12. PMID: 21993765.

35. Dvir T, Timko BP, Brigham MD, Naik SR, Karajanagi SS, Levy O, Jin H, Parker KK, Langer R, Kohane DS. Nanowired three-dimensional cardiac patches. Nat Nanotechnol. 2011 Sep 25;6(11):720-725. doi: 10.1038/nnano.2011.160. PMID: 21946708; PMCID: PMC3208725.

34. Alford PW, Dabiri BE, Goss JA, Hemphill MA, Brigham MD, Parker KK. Blast-induced phenotypic switching in cerebral vasospasm. PNAS. 2011 Aug 2;108(31):12705-12710. doi: 10.1073/pnas.1105860108. Epub 2011 Jul 15. PMID: 21765001; PMCID: PMC3150891.

33. Hemphill MA, Dabiri BE, Gabriele S, Kerscher L, Franck C, Goss JA, Alford PW, Parker KK. A possible role for integrin signaling in diffuse axonal injury. PLoS ONE. 2011 Jul 22;6(7):e22899. doi: 10.1371/journal.pone.0022899. Epub 2011 Jul 22. PMID: 21799943; PMCID: PMC3142195.

32. McCain ML, Parker KK. Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. Pflugers Arch – Eur J Physiol. 2011 Jul;462(1):89–104. doi: 10.1007/s00424-011-0951-4. Epub 2011 Apr 19. PMID: 21499986.

31. Pong T, Adams WJ, Bray MA, Feinberg AW, Sheehy SP, Werdich AA, Parker KK. Hierarchical architecture influences calcium dynamics in engineered cardiac muscle. Exp Biol Med. 2011 March;236(3):366-373. doi: 10.1258/ebm.2010.010239. Epub 2011 Feb 17. PMID: 21330361; PMCID: PMC4501496.

30. Grosberg A, Kuo P-L, Guo C-L, Geisse NA, Bray M-A, Adams WJ, Sheehy SP, Parker KK. Self-organization of muscle cell structure and function. PLoS Comput Biol. 2011 Feb 24;7(2):e1001088. doi: 10.1371/journal.pcbi.1001088. Epub 2011 Feb 24. PMID: 21390276; PMCID: PMC3044763.

29. Vandeparre H, Gabriele S, Brau F, Gay C, Parker KK, Damman P. Hierarchical wrinkling patterns. Soft Matter. 2010 Aug 19;6(22):5751-5756. doi: 10.1039/C0SM00394H

28. Göktepe S, Abilez OJ, Parker KK, Kuhl E. A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis. J Theor Biol. 2010 Aug 7;265(3):433-442. doi: 10.1016/j.jtbi.2010.04.023. Epub 2010 May 4. PMID: 20447409.

27. Bray MA, Adams WJ, Geisse NA, Feinberg AW, Sheehy SP, Parker KK. Nuclear morphology and deformation in engineered cardiac myocytes and tissues. Biomaterials. 2010 Jul;31(19):5143-5150. doi: 10.1016/j.biomaterials.2010.03.028. Epub 2010 Apr 10. PMID: 20382423; PMCID: PMC4416473.

26. Badrossamay MR, McIlwee HA, Goss JA, Parker KKNanofiber assembly by rotary jet spinning. Nanoletters. 2010 Jun 9;10(6):2257-2261. doi: 10.1021/nl101355x. PMID: 20491499; PMCID: PMC3704151.

25. Feinberg AW, Parker KK. Surface-initiated assembly of protein nanofabrics. Nanoletters. 2010 Jun 9;10(6):2184-2191. doi: 10.1021/nl100998p. PMID: 20486679.

24. Alford PW, Feinberg AW, Sheehy SP, Parker KK. Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. Biomaterials. 2010 May;31(13):3613-3621. doi: 10.1016/j.biomaterials.2010.01.079. Epub 2010 Feb 9. PMID: 20149449; PMCID: PMC2838170

23. O’Grady M, Kuo P, Parker KK. Optimization of electroactive hydrogel actuators. ACS Appl Mater Interfaces. 2010 Feb 2;2(2):343-346. doi: 10.1021/am900755w. PMID: 20356178.

22. Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, Shao Y, Wu SM, Parker KK, Chien KR. Generation of functional ventricular heart muscle from mouse ventricular progenitor Cells. Science. 2009 Oct 26;326(5951):426-429. doi: 10.1126/science.1177350. PMID: 19833966; PMCID: PMC2895998. [video download, 1.6 MB]

21. Geisse NA, Sheehy SP, Parker KK.Control of myocyte remodeling in vitro with engineered substrates. In Vitro Cell Dev Biol Anim. 2009 Jul/Aug;45(7):343-350. doi: 10.1007/s11626-009-9182-9. Epub 2009 Feb 28. PMID: 19252956.

20. Sheehy SP, Huang S, Parker KK. Time-warped comparison of gene expression in adaptive and maladaptive cardiac hypertrophy. Circ Cardiovasc Genet. 2009 Apr 1;2(2):116-124. doi: 10.1161/CIRCGENETICS.108.806935. PMCID: PMC2731432; PMID: 20031575

19. Bol M, Reese S, Parker KK, Kuhl K. Computational modeling of muscular thin films for cardiac repair. Computational Mechanics. 2009 March 4;43:535-544. doi: 10.1007/s00466-008-0328-5

18. Chien KR, Domain IJ, Parker KK. Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science. 2008 Dec 5;322(5907):1494-1497. doi: 10.1126/science.1163267. PMID: 19056974.

17. Bray MA, Sheehy SP, Parker KK. Sarcomere alignment is regulated by myocyte shape. Cell Motil Cytoskeleton. 2008 Aug;65:641-651. oi: 10.1002/cm.20290. PMID: 18561184; PMCID: PMC4492320.

16. Parker KK, Tan J, Chen CS, Tung L. Myofibrillar architecture in engineered cardiac myocytes. Circ Res. 2008 Jul 17;103(4):340-342.doi: 10.1161/CIRCRESAHA.108.182469. PMID: 18635822 PMCID: PMC3910252

15. Geisse NA, Feinberg AW, Kuo P, Sheehy S, Bray MA, Parker KK. Micropatterning Approaches for Cardiac Biology. In: Khademhosseini A, Toner M, Borenstein JT, Takayama S, editors. Micro- and Nanoengineering of the Cell Microenvironment: Technologies and Applications. Boston: Artech House; 2008:341-357.

14. O’Grady ML, Parker KK. Dynamic control of protein-protein interactions. Langmuir. 2008 Jan 1;24(1):316-322. doi: 10.1021/la702041g. Epub 2007 Dec 4. PMID: 18052217.

13. Feinberg AW, Feigel A, Shevkoplyas SS, Sheehy S, Whitesides GM, Parker KK. Muscular thin films for building actuators and powering devices. Science. 2007 Sep 7;317:1366-1370. doi: 10.1126/science.1146885. PMID: 17823347. [video download, 11 MB]

12. Parker KK, Ingber DE. Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philos Trans R Soc Lond B Biol Sci. 2007 Aug 29;362(1484):1267-1279. doi: 10.1098/rstb.2007.2114. PMCID: PMC2440395; PMID: 17588874

11. Bray MA, Geisse NA, Parker KK. Multidimensional detection and analysis of Ca2+ sparks in cardiac myocytes. Biophys J. 2007 Jun 15;92(12); 4433-4443. doi: 10.1529/biophysj.106.089359 PMID: 17369419 PMCID: PMC1877778

10. Adams WJ, Pong T, Geisse NA, Sheehy S, Parker KK. Engineering design of a cardiac myocyte. J Computer-Aided Materials Design. 2007 Feb 15;14:19-29. doi: 10.1007/s10820-006-9045-6

9. Brangwynne CP, MacKintosh FC, Kumar S, Geisse NA, Talbot J, Mahadevan L, Parker KK, Ingber DE, Weitz DA. Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Bio. 2006 June 5;173(5):733-741. doi: 10.1083/jcb.200601060. PMID: 16754957; PMCID: PMC2063890.

8. Huang S, Brangwynne CP, Parker KK, Ingber DE. Symmetry-breaking in mammalian cell cohort migration during tissue pattern formation: role of random-walk persistence. Cell Motil Cytoskeleton. 2005 Aug 6;61:201-213. doi: 10.1002/cm.20077 PMID: 15986404

7. Parker KK, Lavelle JA, Taylor LK, Wang Z, Hansen DE. Stretch-induced ventricular arrhythmias during acute ischemia and reperfusion. J Appl Physiol. 2004 Jul 1;97(1):377-383. doi: 10.1152/japplphysiol.01235.2001 PMID: 15220320

6. Latimer DC, Roth BJ, Parker KK. Analytical model for predicting mechanotransduction effects in engineered cardiac tissue. Tissue Eng. 2003 April;9(2):283-289. doi: 10.1089/107632703764664747. PMID: 12740090.

5. Bursac N, Parker KK, Iravanian S, Tung L. Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle. Circ Res. 2002 Dec 13;91(12):e45-e54. doi: 10.1161/01.RES.0000047530.88338.EB PMID: 12480825

4. Parker KK, Brock AL, Brangwynne C, Mannix RJ, Wang N, Ostuni E, Geisse NA, Adams JC, Whitesides GM, Ingber DE. Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J. 2002 Aug 1;16(10):1195-1204.doi: 10.1096/fj.02-0038com. PMID: 12153987.

3. Parker KK, Taylor LK, Atkinson JB, Hansen DE, Wikswo JP. The effects of tubulin-binding agents on stretch-induced ventricular arrhythmias. Euro J Pharm. 2001 May 31;417(43832):131-140. doi: 10.1016/s0014-2999(01)00856-1 PMID: 11301068

2. Brangwynne C, Huang S, Parker KK, Ingber DE, Ostuni E. Symmetry breaking in cultured mammalian cells. In Vitro Cell Dev Bio. 2001 Jan;36(9):563-565.doi: 10.1007/BF02577523 PMID: 11212140

1. Parker KK, Wikswo JP Jr. A model of the magnetic fields created by single motor unit compound action potentials in skeletal muscle. IEEE Trans Biomed Eng. 1997;44:948-957.doi: 10.1109/10.634647. PMID: 9311164

DSC9881

What's New

DBG licenses technology to Obatala Sciences August 9th, 2021

The DBG has licensed an organ-on-chip technology to New Orleans biotech Obatala Sciences. Obatala will use the technology to build disease platforms for curing obesity, diabetes, and cancer. The collaboration has been covered by businesswire in Harvard Licenses Technology to Obatala Sciences to Advance Discovery in Obesity, Diabetes, and Cancer.

DBG Lab is Operational! March 15th, 2021

After 17 years of outstanding science in Cambridge, the DBG has moved to the Engineering School’s new campus in Allston. As of March 2, the lab is fully operational and has resumed experiments. Thank you to all alumni and current personnel for constantly raising the bar. Stand by for the next chapter of DBG science!

Congratulations to Dr. Megan McCain! March 10th, 2021

Our congratulations go out to DBG alumna, Dr. Megan McCain, who has recently received tenure at University of Southern California!

Farewell to Dr. Suhwan Kim! January 13th, 2021

Congratulations to Dr. Suhwan Kim, who has accepted a position as an Assistant Professor in the Department of Chemical Engineering at Dong-A University in Basun, South Korea! Dr. Kim was an integral part of our brain team for over a year as a postdoctoral fellow. We wish him the best on this next step in his career!

Inaugural Issue — Biophysics Reviews! January 4th, 2021

Dr. Kevin Kit Parker launched Biophysics Reviews, a new peer-reviewed journal for the biophysics research community on December 14. Produced by scientific publisher AIP Publishing, the aims to expand “on the tradition of excellence set by Applied Physics Reviews (APR) by publishing high impact, cutting edge research and reviews that are valuable for both emerging and experienced researchers”.

References:
1. KK Parker, L Longobardi, A Sulicz. “Welcome to Biophysics Reviews, a big tent for the biophysics community”. Biophysics Reviews. 14 Dec 2020; 1(1); 010401. https://doi.org/10.1063/5.0036408.