57. Deravi LF, Golecki HM, and Parker KK. Protein-Based Textiles: Bio-Inspired and Bio-Derived Materials for Medical and Non-Medical Applications. J. Chem. Biol. Interfaces. 2013; 1(1): 25-34
56. Agarwal A, Goss JA, Cho A, McCain ML and Parker KK. Microfluidic heart on a chip for higher throughput pharmacological studies. Lab on a Chip. 2013; 13(18): 3599–608
55. McCain ML, Sheehy SP, Grosberg A, Goss JA, and Parker KK.
Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. PNAS. 2013; 110: 9770-9775.
54. Agarwal A, Farouz Y, Nesmith AP, Deravi LF, McCain ML, Parker KK. Micropatterning Alginate Substrates for In Vitro Cardiovascular Muscle on a Chip.. Adv. Funct. Mater. Adv. Funct. Mater. 2013; 23(30): 3738–46.
53. Nawroth JC, Parker KK. Design standards for engineered tissues. Biotechnol Adv. 2012 Dec 23. doi:pii: S0734-9750(12)00198-X. 10.1016/j.biotechadv.2012.12.005. [Epub ahead of print] PubMed PMID: 23267860.
52. Kuo P, Lee H, Bray MA, Geisse NA, Huang YT, Adams WJ, Sheehy SP, Parker KK. Myocyte shape regulates lateral registry of sarcomeres and contractility. Am. J. Pathol. 2012; 181(6):2030-7.
51. Deravi LF, Su T, Paten JA, Ruberti, JW, Bertoldi K, Parker KK. Differential Contributions of Conformation Extension and Domain Unfolding to Properties of Fibronectin Nanotexiles. Nano Letters. 2012; 12 (11):5587–5592.
50. Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A, Dabiri JO, Parker KK. A tissue-engineered jellyfish with biomimetic propulsion. Nat Biotechnol. 2012;30;792-797.
49. Dabiri BE, Lee H, Parker KK. A potential role for integrin signaling in mechanoelectrical feedback. Prog Biophys Mol Biol. 2012; 110: 196–203.
48. Sheehy SP, Grosberg A, Parker KK. The contribution of cellular mechanotransduction to cardiomyocyte form and function. Biomech Model Mechanobiol. 2012; 11: 1227-1239.
47. McCain ML, Lee H, Aratyn-Schaus Y, Kléber AG, Parker KK. Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle. PNAS. 2012;109:9881-9886.
46. Feinberg AW, Alford PW, Jin H, Ripplinger CM, Werdich AA, Sheehy SP, Grosberg A, Parker KK. Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture. Biomaterials. 2012;33:5732-5741.
45. Beauchamp P, Desplantez T, McCain ML, Li W, Asimaki A, Rigoli G, Parker KK, Saffitz JE, Kleber AG. Electrical Coupling and Propagation in Engineered Ventricular Myocardium With Heterogeneous Expression of Connexin43. Circ Res. 2012;110:1445-1453.
44. Grosberg A, Nesmith AP, Goss JA, Brigham MD, McCain ML, Parker KK. Muscle on a chip: In vitro contractility assays for smooth and striated muscle. J Pharmacol Toxicol Methods. 2012;65:126-135.
43. Desplantez T, McCain ML, Beauchamp P, Rigoli G, Rothen-Rutishauser B, Parker KK, Kleber AG. Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current. Cardiovasc Res. 2012;94:58-65.
42. Shim J, Grosberg A, Nawroth JC, Parker KK, Bertoldi K. Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior. J. Biomech. 2012;45:832-841.
41. Sheehy SP, Parker KK. The Role of Mechanical Forces in Guiding Tissue Differentiation. In: Bernstein H, editor. Tissue Engineering in Regenerative Medicine. Springer; 2011:77-97.
40. Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA, Parker KK. Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. PNAS. 2011;108:19943-19948.
39. McCain ML, Desplantez T, Geisse NA, Rothen-Rutishauser B, Oberer H, Parker KK, Kleber AG. Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance. Am J Physiol Heart Circ Physiol. 2012;302:H443-H450.
38. Mellado P, McIlwee HA, Badrossamay MR, Goss JA, Mahadevan L, Parker KK. A simple model for nanofiber formation by rotary jet-spinning. Appl Phys Lett. 2011;99:203107.
37. Grosberg A, Alford PW, McCain ML, Parker KK. Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip. Lab Chip. 2011;11(24):4165-4173.
36. Alford PW, Nesmith AP, Seywerd, JN, Grosberg A, Parker KK. Vascular smooth muscle contractility depends on cell shape. Integr. Biol. 2011;3(11):1063-1070.
35. Dvir T, Timko BP, Brigham MD, Naik SR, Karajanagi SS, Levy O, Jin H, Parker KK, Langer R, Kohane DS. Nanowired three-dimensional cardiac patches. Nat Nanotechnol. 2011;6:720-725.
34. Hemphill MA, Dabiri BE, Gabriele S, Kerscher L, Franck C, Goss JA, Alford PW, Parker KK. A possible role for integrin signaling in diffuse axonal injury. PLoS ONE. 2011;6:e22899.
33. Alford PW, Dabiri BE, Goss JA, Hemphill MA, Brigham MD, Parker KK. Blast-induced phenotypic switching in cerebral vasospasm. PNAS. 2011;108:12705-12710
32. McCain ML, Parker KK. Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. Pflugers Arch – Eur J Physiol. 2011;462:89–104.
31. Grosberg A, Kuo P-L, Guo C-L, Geisse NA, Bray M-A, Adams WJ, Sheehy SP, Parker KK. Self-organization of muscle cell structure and function. PLoS Comput Biol. 2011;7:e1001088.
30. Pong T, Adams WJ, Bray MA, Feinberg AW, Sheehy SP, Werdich AA, Parker KK. Hierarchical architecture influences calcium dynamics in engineered cardiac muscle. Exp Biol Med. 2011;236:366-373
29. Vandeparre H, Gabriele S, Brau F, Gay C, Parker KK, Damman P. Hierarchical wrinkling patterns. Soft Matter. 2010;6:5751-5756.
28. Bray MA, Adams WJ, Geisse NA, Feinberg AW, Sheehy SP, Parker KK. Nuclear morphology and deformation in engineered cardiac myocytes and tissues. Biomaterials. 2010;31:5143-5150.
27. Badrossamay MR, McIlwee HA, Goss JA, Parker KK. Nanofiber assembly by rotary jet spinning. Nanoletters. 2010;10:2257-2261.
26. Feinberg AW, Parker KK. Surface-initiated assembly of protein nanofabrics. Nanoletters. 2010;10:2184-2191.
25. Göktepe S, Abilez OJ, Parker KK, Kuhl E. A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis. J Theor Biol. 2010;265:433-442.
24. Alford PW, Feinberg AW, Sheehy SP, Parker KK. Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. Biomaterials. 2010;31:3613-3621.
23. O’Grady M, Kuo P, Parker KK. Optimization of electroactive hydrogel actuators. ACS Appl Mater Interfaces. 2010;2:343-346.
22. Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, Shao Y, Wu SM, Parker KK, Chien KR. Generation of functional ventricular heart muscle from mouse ventricular progenitor Cells. Science. 2009;326(5951):426-429. [video download, 1.6 MB]
21. Geisse NA, Sheehy SP, Parker KK.Control of myocyte remodeling in vitro with engineered substrates. In Vitro Cell Dev Biol Anim. 2009;45:343-350.
20. Sheehy SP, Huang S, Parker KK. Time-warped comparison of gene expression in adaptive and maladaptive cardiac hypertrophy. Circ Cardiovasc Genet. 2009;2:116-124.
19. Bol M, Reese S, Parker KK, Kuhl K. Computational modeling of muscular thin films for cardiac repair. Computational Mechanics. 2009;43:535-544.
18. Chien KR, Domain IJ, Parker KK. Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science. 2008;322:1494-1497. Review.
17. Parker KK, Tan J, Chen CS, Tung L. Myofibrillar architecture in engineered cardiac myocytes. Circ Res. 2008;103:340-342.
16. Bray MA, Sheehy SP, Parker KK. Sarcomere alignment is regulated by myocyte shape. Cell Motil Cytoskeleton. 2008;65:641-651.
15. Geisse NA, Feinberg AW, Kuo P, Sheehy S, Bray MA, Parker KK. Micropatterning Approaches for Cardiac Biology. In: Khademhosseini A, Toner M, Borenstein JT, Takayama S, editors. Micro- and Nanoengineering of the Cell Microenvironment: Technologies and Applications. Boston: Artech House; 2008:341-357.
14. O’Grady ML, Parker KK. Dynamic control of protein-protein interactions. Langmuir. 2008;24:316-322.
13. Feinberg AW, Feigel A, Shevkoplyas SS, Sheehy S, Whitesides GM, Parker KK. Muscular thin films for building actuators and powering devices. Science. 2007;317:1366-1370. [video download, 11 MB]
12. Parker KK, Ingber DE. Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philos Trans R Soc Lond B Biol Sci. 2007;362:1267-1279.
11. Bray MA, Geisse NA, Parker KK. Multidimensional detection and analysis of Ca2+ sparks in cardiac myocytes. Biophys J. 2007;92:4433-4443. [source code / test data]
10. Adams WJ, Pong T, Geisse NA, Sheehy S, Parker KK. Engineering design of a cardiac myocyte. J Computer-Aided Materials Design. 2007;14:19-29.
9. Brangwynne CP, MacKintosh FC, Kumar S, Geisse NA, Talbot J, Mahadevan L, Parker KK, Ingber DE, Weitz DA. Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Bio. 2006;173:733-741.
8. Huang S, Brangwynne CP, Parker KK, Ingber DE. Symmetry-breaking in mammalian cell cohort migration during tissue pattern formation: role of random-walk persistence. Cell Motil Cytoskeleton. 2005;61:201-213.
7. Parker KK, Lavelle JA, Taylor LK, Wang Z, Hansen DE. Stretch-induced ventricular arrhythmias during acute ischemia and reperfusion. J Appl Physiol. 2004;97:377-383.
6. Latimer DC, Roth BJ, Parker KK. Analytical model for predicting mechanotransduction effects in engineered cardiac tissue. Tissue Eng. 2003;9:283-289.
5. Bursac N, Parker KK, Iravanian S, Tung L. Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle. Circ Res. 2002;91:e45-e54.
4. Parker KK, Brock AL, Brangwynne C, Mannix RJ, Wang N, Ostuni E, Geisse NA, Adams JC, Whitesides GM, Ingber DE. Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J. 2002;16:1195-1204.
3. Parker KK, Taylor LK, Atkinson JB, Hansen DE, Wikswo JP. The effects of tubulin-binding agents on stretch-induced ventricular arrhythmias. Euro J Pharm. 2001;417:131-140.
2. Brangwynne C, Huang S, Parker KK, Ingber DE, Ostuni E. Symmetry breaking in cultured mammalian cells. In Vitro Cell Dev Bio. 2001;36:563-565.
1. Parker KK, Wikswo JP Jr. A model of the magnetic fields created by single motor unit compound action potentials in skeletal muscle. IEEE Trans Biomed Eng. 1997;44:948-957.
Graduate Studies in the DBG December 6th, 2013
Folks, there is more email traffic from PhD applicants than I can respond to. I have posted previously on what your application should look like, so scroll thru our News to see specifics.
Here are the first things I look at when I review an application:
1. Your math (this filters out about 90% of the applicants with BME undergraduate degrees…gotta take PDEs and complex variables)
2. Your lab experience
3. Your grades
4. Your reference letters. If the best thing your letter writer can say is that you sat in front of class, asked questions, turned in HWs, and got an A in the class, that doesn’t really distinguish you.
5. Your essays. Nothing is done until its published. If you can’t write a good response to an essay question, with good English, sentence and paragraph structure, I can’t take you.
Welcome to the DBG December 5th, 2013
The DBG would like to welcome Isabelle Huggler from the Department Health Sciences and Technology at ETH, Zurich. Isabelle completed her Bachelor studies in Food Engineering in August 2013 and she has joined the DBG for an internship for three months before she returns to ETH to start her studies for a Masters. Isabelle will be working on a project that will draw on her Food Engineering expertise. Welcome Isabelle!
Welcome to the DBG November 22nd, 2013
The DBG welcomes Thomas Grevesse as our most recent Post Doctoral Fellow. He will join the Traumatic Brain Injury Team. Thomas comes from Professor Sylvain Gabriele’s Mechanobiology & Soft Matter group at the University of Mons in Belgium, where is recently received his Ph.D. Please join us in welcoming Thomas to the DBG.
Current Images from the DBG November 1st, 2013
A sea horse shaped Cardiomyocytes stained with alpha-actinin in green, actin in red and DAPI in blue. Image by Stephanie Dauth and Moran Yadid.
Welcome back to the DBG!! October 7th, 2013
The DBG would like to welcome back Janna Nawroth as the latest postdoctoral fellow to join the team. Janna was part of the DBG for a couple of years while she was a graduate student at Cal Tech. Janna has been working in the labs of her adviser Professor John O. Dabiri, since receiving her Ph.D. in December of 2012. Welcome Back Janna!!