Publications
43. Desplantez T, McCain ML, Beauchamp P, Rigoli G, Rothen-Rutishauser B, Parker KK, Kleber AG. Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current. Cardiovasc Res. 2012;94:58-65.
42. Shim J, Grosberg A, Nawroth JC, Parker KK, Bertoldi K. Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior. J. Biomech. 2012;45:832-841.
41. Sheehy SP, Parker KK. The Role of Mechanical Forces in Guiding Tissue Differentiation. In: Bernstein H, editor. Tissue Engineering in Regenerative Medicine. Springer; 2011:77-97.
40. Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA, Parker KK. Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. PNAS. 2011;108:19943-19948.
39. McCain ML, Desplantez T, Geisse NA, Rothen-Rutishauser B, Oberer H, Parker KK, Kleber AG. Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance. Am J Physiol Heart Circ Physiol. 2012;302:H443-H450.
38. Mellado P, McIlwee HA, Badrossamay MR, Goss JA, Mahadevan L, Parker KK. A simple model for nanofiber formation by rotary jet-spinning. Appl Phys Lett. 2011;99:203107.
37. Grosberg A, Alford PW, McCain ML, Parker KK. Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip. Lab Chip. 2011;11(24):4165-4173.
36. Alford PW, Nesmith AP, Seywerd, JN, Grosberg A, Parker KK. Vascular smooth muscle contractility depends on cell shape. Integr. Biol. 2011;3(11):1063-1070.
35. Dvir T, Timko BP, Brigham MD, Naik SR, Karajanagi SS, Levy O, Jin H, Parker KK, Langer R, Kohane DS. Nanowired three-dimensional cardiac patches. Nat Nanotechnol. 2011;6:720-725.
34. Hemphill MA, Dabiri BE, Gabriele S, Kerscher L, Franck C, Goss JA, Alford PW, Parker KK. A possible role for integrin signaling in diffuse axonal injury. PLoS ONE. 2011;6:e22899.
33. Alford PW, Dabiri BE, Goss JA, Hemphill MA, Brigham MD, Parker KK. Blast-induced phenotypic switching in cerebral vasospasm. PNAS. 2011;108:12705-12710
32. McCain ML, Parker KK. Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. Pflugers Arch – Eur J Physiol. 2011;462:89–104.
31. Grosberg A, Kuo P-L, Guo C-L, Geisse NA, Bray M-A, Adams WJ, Sheehy SP, Parker KK. Self-organization of muscle cell structure and function. PLoS Comput Biol. 2011;7:e1001088.
30. Pong T, Adams WJ, Bray MA, Feinberg AW, Sheehy SP, Werdich AA, Parker KK. Hierarchical architecture influences calcium dynamics in engineered cardiac muscle. Exp Biol Med. 2011;236:366-373
29. Vandeparre H, Gabriele S, Brau F, Gay C, Parker KK, Damman P. Hierarchical wrinkling patterns. Soft Matter. 2010;6:5751-5756.
28. Bray MA, Adams WJ, Geisse NA, Feinberg AW, Sheehy SP, Parker KK. Nuclear morphology and deformation in engineered cardiac myocytes and tissues. Biomaterials. 2010;31:5143-5150.
27. Badrossamay MR, McIlwee HA, Goss JA, Parker KK. Nanofiber assembly by rotary jet spinning. Nanoletters. 2010;10:2257-2261.
26. Feinberg AW, Parker KK. Surface-initiated assembly of protein nanofabrics. Nanoletters. 2010;10:2184-2191.
25. Göktepe S, Abilez OJ, Parker KK, Kuhl E. A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis. J Theor Biol. 2010;265:433-442.
24. Alford PW, Feinberg AW, Sheehy SP, Parker KK. Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. Biomaterials. 2010;31:3613-3621.
23. O’Grady M, Kuo P, Parker KK. Optimization of electroactive hydrogel actuators. ACS Appl Mater Interfaces. 2010;2:343-346.
22. Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, Shao Y, Wu SM, Parker KK, Chien KR. Generation of functional ventricular heart muscle from mouse ventricular progenitor Cells. Science. 2009;326(5951):426-429. [video download, 1.6 MB]
21. Geisse NA, Sheehy SP, Parker KK.Control of myocyte remodeling in vitro with engineered substrates. In Vitro Cell Dev Biol Anim. 2009;45:343-350.
20. Sheehy SP, Huang S, Parker KK. Time-warped comparison of gene expression in adaptive and maladaptive cardiac hypertrophy. Circ Cardiovasc Genet. 2009;2:116-124.
19. Bol M, Reese S, Parker KK, Kuhl K. Computational modeling of muscular thin films for cardiac repair. Computational Mechanics. 2009;43:535-544.
18. Chien KR, Domain IJ, Parker KK. Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science. 2008;322:1494-1497. Review.
17. Parker KK, Tan J, Chen CS, Tung L. Myofibrillar architecture in engineered cardiac myocytes. 2008;103:340-342.
16. Bray MA, Sheehy SP, Parker KK. Sarcomere alignment is regulated by myocyte shape. Cell Motil Cytoskeleton. 2008;65:641-651.
15. Geisse NA, Feinberg AW, Kuo P, Sheehy S, Bray MA, Parker KK. Micropatterning Approaches for Cardiac Biology. In: Khademhosseini A, Toner M, Borenstein JT, Takayama S, editors. Micro- and Nanoengineering of the Cell Microenvironment: Technologies and Applications. Boston: Artech House; 2008:341-357.
14. O’Grady ML, Parker KK. Dynamic control of protein-protein interactions. Langmuir. 2008;24:316-322.
13. Feinberg AW, Feigel A, Shevkoplyas SS, Sheehy S, Whitesides GM, Parker KK. Muscular thin films for building actuators and powering devices. Science. 2007;317:1366-1370. [video download, 11 MB]
12. Parker KK, Ingber DE. Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philos Trans R Soc Lond B Biol Sci. 2007;362:1267-1279.
11. Bray MA, Geisse NA, Parker KK. Multidimensional detection and analysis of Ca2+ sparks in cardiac myocytes. Biophys J. 2007;92:4433-4443. [source code / test data]
10. Adams WJ, Pong T, Geisse NA, Sheehy S, Parker KK. Engineering design of a cardiac myocyte. J Computer-Aided Materials Design. 2007;14:19-29.
9. Brangwynne CP, MacKintosh FC, Kumar S, Geisse NA, Talbot J, Mahadevan L, Parker KK, Ingber DE, Weitz DA. Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Bio. 2006;173:733-741.
8. Huang S, Brangwynne CP, Parker KK, Ingber DE. Symmetry-breaking in mammalian cell cohort migration during tissue pattern formation: role of random-walk persistence. Cell Motil Cytoskeleton. 2005;61:201-213.
7. Parker KK, Lavelle JA, Taylor LK, Wang Z, Hansen DE. Stretch-induced ventricular arrhythmias during acute ischemia and reperfusion. J Appl Physiol. 2004;97:377-383.
6. Latimer DC, Roth BJ, Parker KK. Analytical model for predicting mechanotransduction effects in engineered cardiac tissue. Tissue Eng. 2003;9:283-289.
5. Bursac N, Parker KK, Iravanian S, Tung L. Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle. Circ Res. 2002;91:e45-e54.
4. Parker KK, Brock AL, Brangwynne C, Mannix RJ, Wang N, Ostuni E, Geisse NA, Adams JC, Whitesides GM, Ingber DE. Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J. 2002;16:1195-1204.
3. Parker KK, Taylor LK, Atkinson JB, Hansen DE, Wikswo JP. The effects of tubulin-binding agents on stretch-induced ventricular arrhythmias. Euro J Pharm. 2001;417:131-140.
2. Brangwynne C, Huang S, Parker KK, Ingber DE, Ostuni E. Symmetry breaking in cultured mammalian cells. In Vitro Cell Dev Bio. 2001;36:563-565.
1. Parker KK, Wikswo JP Jr. A model of the magnetic fields created by single motor unit compound action potentials in skeletal muscle. IEEE Trans Biomed Eng. 1997;44:948-957.
What's New
Picture of the Month – April 2012 April 6th, 2012
Isotropic cardiac myocyte monolayer stained for actin (red), beta-catenin (white), and nuclear DNA (blue). Image by Megan McCain, Parker lab.
Congrats to Kartik Balachandran! March 14th, 2012
Kartik Balachandran has been awarded the Postdoctoral Fellow Best Abstract Award by the Association of Scientists of Indian Origin Special Interest Group of the Society of Toxicology (SOT) at the SOT Annual Meeting in San Francisco, CA. This competitive award was based on a submitted abstract and a cover letter outlining the significance of his research. The award includes a plaque and monetary award of $500. Congratulations, Kartik!!
Congrats to Josh Goss!! March 5th, 2012
Josh Goss is one of the winners of the first Harvard School of Engineering and Applied Sciences Dean’s Excellence Award. Josh is the senior instrumentation engineer and staff scientists in the Disease Biophysics Group, designing and prototyping all of our experimental systems from microfluidic systems for organs on chips to blast bioreactors for brain injury research. Congratulations, Josh!! Thanks for all of your hard work!!
Picture of the Month – February 2012 February 24th, 2012
Micropatterned mouse ventricular muscle cells assembled into an anisotropic tissue showing nuclei (pink) and organized sarcomeres (orange). This organization recapitulates features of the native architecture of cardiac tissue. Image by Anna Grosberg, Parker lab.
Postdoctoral Positions in the DBG February 19th, 2012
We have several postdoctoral positions opening now and in the coming months. We are especially interested in candidates with backgrounds in theoretical biomechanics who are interested in conducting bench experiments. These positions will focus on our efforts to recapitulate organ-level function on chips for drug discovery and safety pharmacology.
All of these positions require a doctoral degree in an appropriate field and a demonstrated publication record. Applications in the form of a single PDF file containing a cover letter, resume, and up to three examples of first author papers should be forwarded to Prof Parker (kkparker@seas.harvard.edu). A list of references should be submitted with the resume with contact information.