Recent Abstracts

  1. McIlwee HA, Badrossamay MR, Goss, JA, Parker KK. Parametric Study of Nanofiber Formation by Rotary Jet-Spinning. Materials Research Society (MRS) Fall Meeting, Boston, MA, November 2011.
  2. McIlwee HA, Badrossamay MR, Deravi LF, Goss, JA, Parker KK. Novel Method of Fibronectin Fibrillogenesis by Rotary Jet-Spinning. Materials Research Society (MRS) Fall Meeting, Boston, MA, November 2011.
  3. Farouz Y, Agarwal A, McCain ML, Parker KK. Alginate-based muscular thin films for in vitro cardiac contractility assays. Materials Research Society (MRS) Fall Meeting, Boston, MA, November 2011.
  4. Badrossamay MR, Goss JA, Parker KK. Pull-Spinning: A Rapid Prototyping of Nano-Scale Fibrous Assemblies. Materials Research Society (MRS) Fall Meeting, Boston, MA, November 2011.
  5. Badrossamay MR, McCain M, Parker KK. Bio-Hybrid Materials for Cardiac Tissue Engineering: Bio-Functionality and in-vitro Bio-degradation. Materials Research Society (MRS) Fall Meeting, Boston, MA, November 2011.
  6. Deravi LF, Bell G, Magyar A, McIlwee HA, Mathger L, Kuzirian A, Hu E, Hanlon R, Parker, KK. Assembly of Bio-Photonic Materials using Proteins Isolated from cuttlefish Sepia officinalis. Materials Research Society (MRS) Fall Meeting, Boston, MA, November 2011.
  7. McIlwee HA, Badrossamay MR, Deravi LF, Goss, JA, Parker KK. Novel Method of Fibronectin Fibrillogenesis by Rotary Jet-Spinning. Biomedical Engineering Society (BMES) Annual Meeting, Hartford, CT, October 2011.
  8. Farouz Y, Agarwal A, McCain ML, Parker KK. Alginate-based muscular thin films for in vitro cardiac contractility assays. Biomedical Engineering Society (BMES) Annual Meeting, Hartford, CT, October 2011.
  9. Sheehy SP, Qin P, Gordon E, Grosberg A, Yoon L, Falls JG, Goss JA, Pipes T, Xu X, Willette R, Hu E, Parker KK. Anisotropy Promotes a Mature Gene Expression Profile in Cultured Neonatal Rat Ventricular Myocytes. Biomedical Engineering Society (BMES) Annual Meeting, Hartford, CT, October 2011.
  10. Grosberg A, Alford PW, McCain ML, Nesmith AP, Parker, KK. Heart on a Chip: Measuring Structure-Function Relationship of Cardiac Tissue. Biomedical Engineering Society (BMES) Annual Meeting, Hartford, CT, October 2011.
  11. Deravi LF, Alford PW, Dabiri B, Grosberg A, Parker KK. Molecular Changes in Protein nanoFabrics. Biomedical Engineering Society (BMES) Annual Meeting, Hartford, CT, October 2011.
  12. Deravi LF, Hemphill MA, Grosberg A, Dabiri B, Parker KK. In vitro Models of Neurodegenerative Diseases with Engineered Amyloid Beta Plaques. Biomedical Engineering Society (BMES) Annual Meeting, Hartford, CT, October 2011.
  13. Badrossamay MR, Exilus R, Goss JA, McCain M, Parker KK. ECM-Hybrid Scaffold for Cardiac Tissue Engineering. Biomedical Engineering Society (BMES) Annual Meeting, Hartford, CT, October 2011.
  14. Badrossamay MR, Deravi L, McIlwee HA, Feinberg, AW, Goss JA, Parker KK. De novo Assembly of Extracellular Matrix Proteins, New Frontiers in Fiber Material Science, Charleston, SC, October 2011.
  15. Deravi LF, Alford PW, Dabiri B, Grosberg A, Parker KK. Molecular Changes in Protein nanoFabrics, American Chemical Society Meeting (ACS), Denver, CO, August 2011.
  16. McIlwee HA, Badrossamay MR, Goss, JA, Parker KK. Parametric Study of Nanofiber Formation by Rotary Jet-Spinning. International Materials Research Congress (IMRC) Annual Meeting, Cancun, Mexico. August 2011.
  17. Dabiri BE, Kerscher L, Franck C, Hemphill MA, Goss JA, Alford PW, Parker KK. In Vitro Focal Adhesion Complex Manipulation in Single Neurons: A Model for Traumatic Brain Injury. Biomedical Engineering Society (BMES) Annual Meeting, Austin, TX. October 2010.
  18. Hemphill MA, Dabiri BE, Goss JA, Alford PW, Parker KK. Integrin Mediated Injury in Neurons: A Role for Mechanotransduction in Mild Traumatic Brain Injury. Biomedical Engineering Society (BMES) Annual Meeting, Austin, TX. October 2010.
  19. Grosberg A, Brigham M, Parker KK. A tissue scale, in vitro, combination contractility and electrophysiological assay. Biomedical Engineering Society (BMES) Annual Meeting, Austin, TX. October 2010.
  20. Grosberg A, McCain ML, Parker KK. Self-Organization of a Two Cell Muscle Tissue: Theory and Experiment. Biomedical Engineering Society (BMES) Annual Meeting, Austin, TX. October 2010.
  21. McCain ML, Desplantez T, Geisse NA, Hinnen H, Kleber AG, Parker KK. Electrical Coupling of Ventricular Myocytes is Dependent on Cx43 Density and Myofibril Organization. Biomedical Engineering Society (BMES) Meeting, Austin, TX. October 2010.
  22. McCain ML, Brigham M, Feinberg AW, Alford PW, Sheehy SP, Grosberg A, Goss JA, Parker KK. Engineering Cardiac Form and Function through Cyclic Stretch and Extracellular Matrix Patterning. Biomedical Engineering Society (BMES) Meeting, Austin, TX. October 2010.
  23. Badrossamay MR, McIlwee HA, Goss, JA, Parker KK. Rotary Jet-Spinning: A Novel Technique of Nanofibrous Scaffold Fabrication. Biomedical Engineering Society (BMES) Annual Meeting, Austin, TX. October 2010.
  24. Balachandran K, Wylie-Sears J, Bischoff J, Aikawa E, Levine RA, Parker KK. Cyclic Stretch Induces Endothelial to Mesenchymal Transdifferentiation in Mitral Valve Endothelial Cells. Biomedical Engineering Society (BMES) Annual Meeting, Austin, TX. October 2010.
  25. Alford PW, Goss JA, Brigham MD, Feinberg AW, Parker KK. In Vitro Vasospasms: Acute Traumatic Injury and Vascular Hypercontractility. Biomedical Engineering Society (BMES) Annual Meeting, Austin, TX. October 2010.
  26. Alford PW, Goss JA, Brigham MD, Feinberg AW, Parker KK. In Vitro Vasospasms: Acute Traumatic Injury and Vascular Hypercontractility. Biomedical Engineering Society (BMES) Annual Meeting, Austin, TX. October 2010.
  27. Grosberg A, Brigham M, Goss JA, Alford PA, Parker KK. A tissue scale, in vitro, multiplex contractility assay. Safety Pharmacology Society Annual Meeting, Boston, MA. September 2010.
  28. Grosberg A, Brigham M, Parker KK. Translation to higher throughput: An In vitro, combination contractility and electrophysiological assay. ISACB Biannual Meeting, Cambridge, MA. September 2010.
  29. Balachandran K, Wylie-Sears J, Bischoff J, Aikawa E, Levine R, Parker KK. Cyclic Stretch Induces Alignment and Differentiation of Mitral Valve Endothelial Cells. ISACB Biannual Meeting, Cambridge, MA. September 2010.
  30. Alford PW, Goss JA, Brigham M, Feinberg AW, Parker KK. Hypercontractility Due To Acute Vascular Injury In Vitro: Mechanisms for Cerebral Vasospasms in Traumatic Brain Injury. National Neurotrauma Symposium, Las Vegas, NV. June 2010.
  31. Hemphill MA, Dabiri BE, Goss JA, Alford PW, Parker KK. Acute Mechanical Injury in Neurons: A Role For Integrin Signaling In Traumatic Brain Injury. National Neurotrauma Symposium, Las Vegas, NV. June 2010.
  32. Dabiri BE, Hemphill MA, Kerscher L, Franck C, Goss JA, Alford PW, Parker KK. Focal Adhesion Complex Activation in Single Neurons: A Mechanism for Traumatic Brain Injury. National Neurotrauma Symposium, Las Vegas, NV. June 2010.
  33. Hemphill MA, Dabiri BE, Kerscher L, Franck C, Goss JA, Parker KK. Maladaptive Neural Remodeling in Response to Integrin-Mediated Injury In Vitro. Keystone Synapse: Formation, Function, and Misfunction Snowbird, UT. April 2010.
  34. Feinberg AW, Parker KK. De Novo Regeneration of the Hierarchical Extracellular Matrix with Protein nanoFabrics. Materials Research Society (MRS) Fall Meeting, Boston, MA. November 2009.
  35. Grosberg A, Feinberg AW, Goss JA, Alford PW, Parker KK. A Device for in vitro, High Throughput Cell Tissue Contractility Assay. Materials Research Society (MRS) Fall Meeting, Boston, MA. November 2009.
  36. Badrossamay MR, Goss JA, Parker KK. Fabrication of Well-aligned 3D Nanofibrous Scaffold through Jet-Spinning System. Materials Research Society (MRS) Fall Meeting, Boston, MA. November 2009.
  37. McCain ML, Desplantez T, Beauchamp P, Geisse NA, Rigoli G, Parker KK, Kleber AG. Electrical properties and connexin distribution in micropatterned atrial myocytes with altered connexin 43 genotypes. Heart Rhythm Society’s Scientific Sessions, Boston, MA. May 2009.
  38. McCain ML, Desplantez T, Geisse NA, Oberer H, Parker KK, Kleber AG. Relating electrical conductance, connexin 43 immunostaining, and cell shape in micropatterned cardiac cell pairs. Biophysical Society Annual Meeting, Boston, MA. March 2009.
  39. Adams WJ, O’Grady ML, Kaustabh G, Gibbs AD, Ingber DE, Parker KK. Viscoelastic indentation of extremely soft biological samples. Biophysical Society Annual Meeting, Boston, MA. March 2009.
  40. Feinberg AW, Alford PW, Ripplinger CM, Adams WJ, Sheehy SP, Parker KK. Engineering cardiac contractility from the sarcomere to tissue-scale. Biophysical Society 53rd Annual Meeting, Boston, MA. March 2009.
  41. Feinberg AW, Ripplinger CM, Sheehy SP, Parker KK. Microscale heterogeneities enhance sarcomere alignment and contractile force in engineered myocardium. Materials Research Society (MRS) Fall Meeting, Boston, MA. December 2008.
  42. O’Grady ML, Parker KK. Hierarchical biomimetic design of artificial muscle hydrogels. Materials Research Society (MRS) Fall Meeting, Boston, MA. December 2008.
  43. Feinberg AW, Sheehy SP, Parker KK. Sarcomere alignment dictates contractile force in engineered myocardium. Biomedical Engineering Society (BMES) Annual Meeting, St Louis, MO. October 2008.
  44. Feinberg AW, Sheehy SP, Parker KK. Engineered boundary conditions direct cardiac myogenesis and contractility. Union of the Swiss Societies for Experimental Biology – Biology Meets Engineering, Lausanne, Switzerland. February 2008.
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What's New

Post-Doc Opening: Rapid Manufacturing of Regenerative Heart Valves May 7th, 2018

Prof. Kevin Kit Parker’s Disease Biophysics Group at the Harvard University Wyss Institute for Biologically Inspired Engineering seeks a talented post-doctoral fellow to work on the rapid manufacturing of regenerative heart valves, or JetValves. The candidate will use the proprietary rotary jet spinning technologies developed in the Parker lab to design, build, and test heart valve replacements using natural and synthetic polymeric nanofibers. The goal of this translational project – which is part of an international collaboration with the University of Zurich in Switzerland – is to complete the preclinical characterization of JetValves in preparation for a first-in-man clinical trial.

 

Application Procedure

Interested candidates should submit their application packet to Prof. Kevin Kit Parker (kkparker@g.harvard.edu) and his admin assistant Dr. Ben Smith (bdsmith@g.harvard.edu) as a single pdf file with the following documents: cover letter, CV, 3 relevant papers, and the names of three referees.

More details found at: https://wyss.harvard.edu/job/rapid-manufacturing-of-regenerative-heart-valves/

 

Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.

DBGer Professors!! May 4th, 2018

Kit had an opportunity to spend time with some of the former DBGers who have now joined the ranks of the community of scholars. At the Keystone Conference in Big Sky Montana, he spent time with (shown in photo) Professor Megan McCain from the University of Southern California, Professor Ashutosh Agarwal at the University of Miami, and the newly minted Professor Ben Maoz, Tel Aviv University! On his recent trip to Seoul, Kit spent time with Professor Hyunksuk Lee at Yonsei University. We are proud of all of our alumni and grateful to see them out doing great things!

Congrats DBGers Medical School Bound! May 4th, 2018

The DBG celebrates a 100% success rate with its medical school applicants this year. Tara Murty will be attending Stanford Medical School, Madeleine Dahl will be attending Robert Wood Johnson School of Medicine, Charles Alver will enter the Medical Scientist Training Program at the University of Miami, and Danielle Sawka has been accepted to the BA,MD program at Brown University. Congratulations!!

Congratulations to John Ferrier for winning the 2017 LG UltraWide Festival October 18th, 2017

The DBG would like to congratulate one of our lab managers, John Ferrier, on winning the 2017 LG UltraWide Festival which was hosted by Linus Tech Tips and Austin Evans!

DBG Nanofibers Merge with Art by Carla Ciuffo August 23rd, 2017

The Disease Biophysics Group would like to congratulate and thank Tennessee based artist Carla Ciuffo in her efforts to integrate our nanofibers into her art exhibit “Cosmic Garden” at Tinney Contemporary, opening this Saturday.

“Tundra,” 2017, polished acrylic with floating museum back frame, 48×48 on display at Tinney Contemporary. (Photo: Photo courtesy of the gallery)