Primary Investigators: Matthew Hemphill, Borna Dabiri, Josue Goss
|Figure: In vitro model of TBI in a population of neurons
In order to further elucidate the cellular mechanisms underlying neuronal injury, we employ a technique called Magnetic Tweezers to deliver a local mechanical stimulus to specific regions of the neuron. This technique consists of using an electromagnet to pull on small magnetic beads which are bound to the neuron. By coating the beads with various compounds, we can control the cellular structures through which forces are delivered to the neuron. We have recently found that when we deliver forces through beads coated with fibronectin (FN), an extracellular matrix protein which has binding sites for specific integrin receptors, the extent of injury is much greater than when beads are coated with a substance that does not specifically bind integrins. These results are consistent with the high speed stretcher experiments and suggest that integrin mediated mechanical injury may be a possible explanation of neuronal injury following TBI.
|Figure: In vitro model of TBI in a single neuron
Primary Investigators: Patrick Alford, Ph.D; Sam Felton
|Figure: In vitro model of TBI in the vasculature
Congratulations to Karaghen Hudson, Leila Deravi & Nina Sinatra on the cover of Macromolecular Materials and Engineering! March 27th, 2017
Parker Lab Artist Karaghen Hudson’s illustration accompanying Leila Deravi & Nina Sinatra’s paper “Design and Fabrication of Fibrous Nanomaterials Using Pull Spinning” was chosen for the March 2017 cover of Macromolecular Materials and Engineering.
Pull spinning is a new nanofiber manufacturing technique that uses a high-speed rotating bristle to draw anisotropic nanofibers from a polymer solution. The versatile structure and composition of scaffolds formed using pull spinning enables a wide range of applications, including muscle tissue engineering and textile design.
Congratulations to George Touloumes! March 21st, 2017
Congratulations to Parker Lab PhD student George Touloumes who has been awarded an NSF Graduate Research Fellowship.
Congratulations to Ben Pope! March 21st, 2017
Congratulations to Parker Lab Postdoc Ben Pope who was recently awarded a Life Sciences Research Foundation Fellowship sponsored by the Good Ventures Foundation.
Congratulations Grant Gonzalez and Michael Rosnach on the cover of Macromolecular Materials and Engineering! January 23rd, 2017
Parker Lab Artist Michael Rosnach’s illustration accompanying PhD Student Grant Gonzalez’s paper “Production of synthetic, para-aramid and biopolymer nanofibers by immersion rotary jet-spinning” was chosen for the January 2017 cover of Macromolecular Materials and Engineering.
“Utilizing a precipitant vortex, a novel nanofiber platform produces Kevlar, nylon, DNA, and alginate nanofibers for high-performance composites and tissue engineering applications.”
Congratulations to Ian Perkins & Alex Cho! January 5th, 2017
The DBG would like to congratulate Ian Perkins and Alex Cho who both graduated from Northeastern University in December. Ian received his B.S. in Mechanical Engineering and Alex his B.S. in Biology. We would like to thank you both for your significant contributions to the DBG over the past several years, and we are grateful that you are both continuing with us in the lab this semester!