Microdevices

Overview

Our research is focused on designing and building hybrid materials and devices. Microscale soft biological constructs, which retain their unique biological functionalities, are being interfaced with robust synthetic components to develop two distinct technologies: (1) Active bionanomaterials and (2) Quantitative pharmacological devices.

Muscle on a chip
Higher throughput muscle on a chip
Cardiac valve on a chip

Muscle on a chip

Primary Investigator: Anna Grosberg, Ph.D

The “heart on a chip” is a microdevice that encapsulates multiple pieces of laminar muscle for in vitro studies of tissue contractility, structural properties, and electrophysiological function (Grosberg A, et al. “Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip.” Lab Chip, 2011). The design of such microdevices will give researches and companies an ability to perform tissue scale in vitro experiments to test their cell’s function and/or the effect of pharmacological agents. We are currently working on integrating the “heart on a chip” with other muscle types including stem-cell derived myocytes. Our design efforts are greatly enhanced by our lab’s variety of tools ranging from an optical mapping system and fluorescent microscopes to access to microfab facilities and the muscular thin film technology.

The movie shows a 6 film “heart on a chip”, blue – flat film outline, red – projection tracking

Higher throughput muscle on a chip

Primary Investigator: Ashutosh Agarwal, Ph.D

We are engineering cardiac and vascular smooth muscle cells into spatially organized microtissues on laser cut sub millimeter sized elastomer thin films and hydrogel thin films to give rise to large scale arrays of ‘Muscular Thin Films’ (MTFs) on a chip. The laser cutting procedure is also being employed to batch produce multiple chips in a reproducible and potentially scalable manner. Finally, these chips are being integrated into microfluidic devices to permit high throughput multiplexed analyses. We envision this in vitro technology to serve as an effective pre-clinical screen and hence greatly shorten the timeline and reduce the costs associated with the development of medical therapeutics and products.

Cardiac valve on a chip

Primary Investigator: Kartik Balachandran, Ph.D

We are also interested in developing combinatory “organ on a chip” devices, and one of our research thrusts in this direction is the development of a valve on a chip. Our objective is to design a valve system with neural input that recapitulates the function of a valve in a scaled down on-chip device. This research thrust is motivated from recent secondary valvulotoxic effects of neurological drugs such as diet pills (Fenfluramine-Phentermine) and anti-depressants. We aim to use this device for high throughput testing of neurological and valve function in response to various pharmacological agents.

What's New

DBG Nanofibers Merge with Art by Carla Ciuffo August 23rd, 2017

The Disease Biophysics Group would like to congratulate and thank Tennessee based artist Carla Ciuffo in her efforts to integrate our nanofibers into her art exhibit “Cosmic Garden” at Tinney Contemporary, opening this Saturday.

“Tundra,” 2017, polished acrylic with floating museum back frame, 48×48 on display at Tinney Contemporary. (Photo: Photo courtesy of the gallery)

Thank you to our Summer Students! August 16th, 2017

Thank you to all the undergraduate students who spent time working in the lab over the summer. We wish you all the best this school year!

Jenny Wang, United States Military Academy at West Point
Daniel Gray, United States Military Academy at West Point
Nikita Pereverzin, United States Military Academy at West Point
Kathryn Dula, United States Military Academy at West Point
Daniel Drennan, Nicholls State University
Michael Ferris, James Madison University
Karla Rivera, Barry University
John Doyle, University of Massachusetts at Lowell
Madeleine Dahl, Salem State University
Nikita Budnik, McGill University
Karaghen Hudson, Harvard University
Sayo Eweje, Harvard University
Michael Peters, Harvard University
Gabriela Berner, Harvard University

Welcome Dr. Ardoña! August 15th, 2017

The DBG would like to extend a warm welcome to our newest postdoctoral fellow, Dr. Herdeline Ardoña. Herdeline recently completed her Ph.D. in Chemistry at Johns Hopkins University, where she was a part of Prof. Tovar’s lab. Welcome, Herdeline!

Welcome Dr. Liu! June 23rd, 2017

The DBG would like to extend a warm welcome to our newest postdoctoral fellow, Dr. Qihan Liu. Qihan completed his Ph.D. in Prof. Zhigang Suo’s lab here at Harvard University, where he focused on the mechanics and physics of soft materials. Welcome, Qihan!

Farewell Jack! June 16th, 2017

The DBG would like to wish Jack Zhou all the best as he leaves us for his next adventure – Medical School. Congratulations Jack!