- A new technique of nanofiber fabrication using the rotary jet spinning for regenerative medicine and other industrial applications
- A mathematical model of rotary jet spinning to predict fiber diameter under different processing conditions
- Manufacturing protein nanoFabrics using extracellular matrix proteins
A new technique of nanofiber fabrication using the rotary jet spinning for regenerative medicine and other industrial applications
Primary Investigator: Mohammad R. Badrossamay, Ph.D
FIGURE: Schematic of rotary jet-spinning (RJS) system
A: Rotary jet spinning is capable of forming 3D structures with any arbitrary shape.
B: Scanning electron micrographs of smooth nanofibers (C), decorated (D) and textured (E).
A mathematical model of rotary jet spinning to predict fiber diameter under different processing conditions
Primary Investigator: Holly McIlwee
FIGURE: Three stages of fiber formation in Rotary Jet-Spinning.
A: Jet initiation
B: Jet elongation
C: Solvent evaporation
D: Movie shows nanofiber formation by Rotary Jet-Spinning (RJS) captured by high speed camera
Manufacturing protein nanoFabrics using extracellular matrix proteins for applications ranging from biophotonic devices to neuronal tissue engineering
Primary Investigator: Leila Deravi, Ph.D
We have developed a technique for manufacturing bio-inspired nanoFabrics using the model protein Fibronectin (FN). FN nanoFabrics are synthesized using micro-contact printing onto thermosensitive, polymer substrates. At low temperatures (T< 32ºC), the polymer substrate dissolves, and our pre-patterned protein pops off the substrate as free-standing fibrillar networks, or nanoFabrics. When relaxed FN nanoFabrics are mechanically strained, they exhibit a 6-fold extension without failure, likely due to protein extension under strain. By identifying how mechanical strain affects protein conformation within fabrics, we can begin to design a new range of hyper-elastic textiles with similar chemical properties.
FIGURE: Manufacturing FN nanoFabrics.
A: We built FN networks in the form of nanometer thick fabrics by releasing micropatterned FN from a thermosensitive substrate. Scale bar 20 µm.
B: Atomic force micrograph of FN nanoFabrics after release demonstrates nanoscale thickness.
C: Scanning electron micrograph of FN nanoFabrics after release demonstrates millimeter scale dimensions. Scale bar 50 µm.
Congratulations Grant Gonzalez and Michael Rosnach on the cover of Macromolecular Materials and Engineering! January 23rd, 2017
Parker Lab Artist Michael Rosnach’s illustration accompanying PhD Student Grant Gonzalez’s paper “Production of synthetic, para-aramid and biopolymer nanofibers by immersion rotary jet-spinning” was chosen for the January 2017 cover of Macromolecular Materials and Engineering.
“Utilizing a precipitant vortex, a novel nanofiber platform produces Kevlar, nylon, DNA, and alginate nanofibers for high-performance composites and tissue engineering applications.”
Congratulations to Ian Perkins & Alex Cho! January 5th, 2017
The DBG would like to congratulate Ian Perkins and Alex Cho who both graduated from Northeastern University in December. Ian received his B.S. in Mechanical Engineering and Alex his B.S. in Biology. We would like to thank you both for your significant contributions to the DBG over the past several years, and we are grateful that you are both continuing with us in the lab this semester!
Congratulations Dr. Capulli! December 15th, 2016
Congratulations to Dr. Andrew Capulli who successfully defended his dissertation in December, and will continue in the DBG as a Postdoctoral Fellow.
Congratulations Dr. Nesmith! December 15th, 2016
Congratulations to Dr. Peyton Nesmith who successfully defended his dissertation last month. We wish him the best of luck as he returns to the University of Alabama to complete his M.D.