Bio-Inspired Nanotextiles

Overview


A new technique of nanofiber fabrication using the rotary jet spinning for regenerative medicine and other industrial applications

Primary Investigator: Mohammad R. Badrossamay, Ph.D

We have developed an effective technique for the generation of continuous fibers and non-woven fabrics with nanometer size fiber diameters by using high-speed mechanical rotation of polymeric solutions through a perforated rotary reservoir. Termed, Rotary jet-spinning (RJS), has several advantages in comparison with other nanofiber fabrication methods: (a) the technique does not require high-voltage electric fields, (b) the apparatus is simple to implement, (c) nanofiber structures can be fabricated into an aligned 3D structure or any arbitrary shape by varying the collector geometry, (d) fiber morphology (beaded, textured, or smooth), fiber diameters, and web porosity can be manipulated by altering the process variables, (e) fiber fabrication is independent of solution conductivity, (f) RJS is easily applicable to polymer emulsions and suspensions, and (g) RJS is capable of substantially higher production rates as compared to standard electrospinning.

RJS-system-MBadrossamay.jpg

FIGURE: Schematic of rotary jet-spinning (RJS) system
A: Rotary jet spinning is capable of forming 3D structures with any arbitrary shape.
B: Scanning electron micrographs of smooth nanofibers (C), decorated (D) and textured (E).


A mathematical model of rotary jet spinning to predict fiber diameter under different processing conditions

Primary Investigator: Holly McIlwee

Currently we are studying the formation of nanofibers being produced in our lab via Rotary Jet Spinning from a physical point of view. Using the tools of fluidynamics, we have computed scaling laws that permit us to decrease the diameter and at the same time ensure the continuity of nanofibers, in terms of a few set of tunable laboratory parameters. These scaling laws can be easily translated into phase diagrams for obtaining fibers of desirable characteristics, when design and solution parameters fall into a well defined range.

McIlwee_Fiber_Formation.jpg McIlwee_DBG_Nanofiber_Formation.gif

FIGURE: Three stages of fiber formation in Rotary Jet-Spinning.
A: Jet initiation
B: Jet elongation
C: Solvent evaporation
D: Movie shows nanofiber formation by Rotary Jet-Spinning (RJS) captured by high speed camera


Manufacturing protein nanoFabrics using extracellular matrix proteins for applications ranging from biophotonic devices to neuronal tissue engineering

Primary Investigator: Leila Deravi, Ph.D

We have developed a technique for manufacturing bio-inspired nanoFabrics using the model protein Fibronectin (FN). FN nanoFabrics are synthesized using micro-contact printing onto thermosensitive, polymer substrates. At low temperatures (T< 32ºC), the polymer substrate dissolves, and our pre-patterned protein pops off the substrate as free-standing fibrillar networks, or nanoFabrics. When relaxed FN nanoFabrics are mechanically strained, they exhibit a 6-fold extension without failure, likely due to protein extension under strain. By identifying how mechanical strain affects protein conformation within fabrics, we can begin to design a new range of hyper-elastic textiles with similar chemical properties.

FN-nanoFabrics-LDeravi.jpg
FIGURE: Manufacturing FN nanoFabrics.
A: We built FN networks in the form of nanometer thick fabrics by releasing micropatterned FN from a thermosensitive substrate. Scale bar 20 µm.
B: Atomic force micrograph of FN nanoFabrics after release demonstrates nanoscale thickness.
C: Scanning electron micrograph of FN nanoFabrics after release demonstrates millimeter scale dimensions. Scale bar 50 µm.
Grp_photo_Jan 2014_305W_230H

What's New

Welcome Dr. Cera and Dr. Lee! April 3rd, 2017

The DBG would like to extend a warm welcome to our new postdoctoral fellows, Luca Cera & Keel Yong Lee. Luca comes to us from Berlin, German, where he recently completed his Ph.D. in Chemistry under the guidance of Prof. Dr. Christoph A. Schalley. Keel Yong recently completed his Ph.D. in Prof. Kwanwoo Shin’s lab at Sogang University in Seoul, South Korea. We are looking forward to expanding on our past collaborations with him.

Congratulations to Karaghen Hudson, Leila Deravi & Nina Sinatra on the cover of Macromolecular Materials and Engineering! March 27th, 2017

Parker Lab Artist Karaghen Hudson’s illustration accompanying Leila Deravi & Nina Sinatra’s paper “Design and Fabrication of Fibrous Nanomaterials Using Pull Spinning” was chosen for the March 2017 cover of Macromolecular Materials and Engineering.

 

 

Pull spinning is a new nanofiber manufacturing technique that uses a high-speed rotating bristle to draw anisotropic nanofibers from a polymer solution. The versatile structure and composition of scaffolds formed using pull spinning enables a wide range of applications, including muscle tissue engineering and textile design.

Congratulations to George Touloumes! March 21st, 2017

Congratulations to Parker Lab PhD student George Touloumes who has been awarded an NSF Graduate Research Fellowship.

Congratulations to Ben Pope! March 21st, 2017

Congratulations to Parker Lab Postdoc Ben Pope who was recently awarded a Life Sciences Research Foundation Fellowship sponsored by the Good Ventures Foundation.

Congratulations Grant Gonzalez and Michael Rosnach on the cover of Macromolecular Materials and Engineering! January 23rd, 2017

Parker Lab Artist Michael Rosnach’s illustration accompanying PhD Student Grant Gonzalez’s paper “Production of synthetic, para-aramid and biopolymer nanofibers by immersion rotary jet-spinning” was chosen for the January 2017 cover of Macromolecular Materials and Engineering.

 

mame201600365_Cover Art Submission

 

“Utilizing a precipitant vortex, a novel nanofiber platform produces Kevlar, nylon, DNA, and alginate nanofibers for high-performance composites and tissue engineering applications.”