Research

Our group’s primary research focus is on understanding biological design. This includes nature’s mechanism for mechanotransduction. In this regard, we are interested in how extracellular matrix and cytoskeletal architecture potentiate and modulate the activation of mechanochemical and mechanoelectrical signaling pathways and genetic programs in cardiac, neural, and vascular smooth muscle cells and tissues. In order to study these mechanisms at different spatial scales, we use cellular and tissue engineering techniques that allow us to build custom-designed tissue constructs as experimental preparations.

Our group also has a growing effort in biologically-inspired design. This includes our work with electroactive polymer actuators, bio-inspired photonic systems, nanotextiles, and cell and tissue self-assembly as a system for rapid-prototyping of nonbiological systems.

Current areas of active research include:

Mechanotransduction – the role of mechanical stress, cell shape, and cell architecture on cell function.

Tissue Engineering – development of tissue grafts and scaffolds with unique structures and functions.

Brain Injury – investigating the mechanisms of traumatic brain injury at a cell and tissue scale.

Nanotextiles – developing new techniques for mimicking ECM networks for regenerative medicine and other industrial applications.

Microdevices – designing and building microscale soft biological constructs which retain their unique biological functionalities.

DSC9881

What's New

Farewell Charles Alver! August 13th, 2018

The DBG would like to thank Charles Alver for his time in the group and to wish him the best of luck in the Medical Scientist Training Program at the University of Miami!

Thank you to our 2018 summer students! August 13th, 2018

Thank you the undergraduate students who visited our lab this summer. We wish you all the best in your future endeavors!

 

Sydney Reed, Mississippi State University
Karla Rivera, Barry University
John Doyle, University of Massachusetts at Lowell
Chris Grouard, Bunker Hill Community College
Jesse Palmer, United States Military Academy at West Point
Sayo Eweje, Harvard University
Michael Peters, Harvard University

The DBG welcomes visiting faculty July 27th, 2018

The Disease Biophysics Groups welcomes visiting falculty Professor Renita Horton from Mississippi State University, Professor Kwanwoo Shin from Sogang University, and Colonel John Burpo, the chair of the Chemistry Department at West Point. The Disease Biophysics Group would also like to thank the faculty members for working with our researchers during their visit.

Welcome Summer REU Students and West Point Cadets! July 27th, 2018

The Disease Biophysics Group would like welcome our 2018 summer REU students and West Point Cadets for the summer. Good luck on your research projects!

The Disease Biophysics Group welcomes new Staff member July 27th, 2018

The Disease Biophysics Group would like to welcome our newest staff scientist, Daniel Drennan, to the group!