Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current
Publication information:
42 ., Desplantez T, McCain ML, Beauchamp P, Rigoli G, Rothen-Rutishauser B, Parker KK, and Kleber AG. 2012. “Connexin43 Ablation in Foetal Atrial Myocytes Decreases Electrical Coupling, Partner Connexins, and Sodium Current”. Cardiovascular Research, 94, 1, Pp. 58-65
Abstract
Remodelling and regional gradients in expression of connexins (Cx) are thought to contribute to atrial electrical dysfunction and atrial fibrillation. We assessed the effect of interaction between Cx43, Cx40, and Cx45 on atrial cell-to-cell coupling and inward Na current (INa) in engineered pairs of atrial myocytes derived from wild-type mice (Cx43+/+) and mice with genetic ablation of Cx43 (Cx43−/−).