Diagnostic tools for evaluating the impact of Focal Axonal Swellings arising in neurodegenerative diseases and/or traumatic brain injury
Publication information:
75 ., Maia PD, Hemphill MA, Zehnder B, Zhang C, Parker KK, and Kutz JN. 2015. “Diagnostic Tools for Evaluating the Impact of Focal Axonal Swellings Arising in Neurodegenerative Diseases and Or Traumatic Brain Injury”. Journal of Neuroscience Methods, 30, 253, Pp. 233-43
Abstract
Focal Axonal Swellings arise in several leading neurodegenerative diseases of the central nervous system and are hallmark features of concussions and traumatic brain injuries. Recent theories mapped how the shape of each swelling affects the propagation of spike trains and consequently the information encoded in them. Spikes can be selectively deleted, have their speed affected, or blocked depending upon the severity of the swelling.