Light-triggered Cardiac Microphysiological Model
Publication information:
150., , Shani K, Ardoña HAM, Zimmerman JF, , Lee KY, Jin Q, Bertarelli C, Parker KK, and Lanzani G. 2023. “Light-Triggered Cardiac Microphysiological Model”. APL Bioengineering , 7, 2
Abstract
Light is recognized as an accurate and noninvasive tool for stimulating excitable cells. Here, we report on a non-genetic approach based on
organic molecular phototransducers that allows wiring- and electrode-free tissue modulation. As a proof of concept, we show photostimulation
of an in vitro cardiac microphysiological model mediated by an amphiphilic azobenzene compound that preferentially dwells in the cell membrane.
Exploiting this optical based stimulation technology could be a disruptive approach for highly resolved cardiac tissue stimulation.