The Disease Biophysics Group (DBG) at Harvard University is an interdisciplinary team of biologists, physicists, engineers and material scientists actively researching the structure/function relationship in cardiac, neural, and vascular smooth muscle tissue engineering.
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What's New

Welcome to the DBG!! February 26th, 2015

2015 sees the arrival of one new researcher to the DBG team and the return of one researcher. Mary Kate Macedonia joins us from Case Western University. Kevin Murphy returns to the DBG after some time in the NFL. We are excited to have both of them on the team!

Welcome to New Fellows! February 26th, 2015

The DBG would like to welcome our three newest Post-Doctoral Fellows to the team. Dr. Arun Shrivats completed his Ph.D. at Carnegie Mellon University and joins us after a brief period in industry. Dr. Alanna Gannon completed her Ph.D. at Trinity College. Dr. Dong-Hwee Kim joins us after completing his doctoral studies at Johns Hopkins University. Welcome to the DBG!

Congratulations! January 24th, 2015

Congratulations to David Boyle on his retirement from Harvard!! Thank you, David, for your years of service to Harvard and to the DBG and good luck in your future endeavors. You will be missed!!

Congratulations to Megan McCain September 4th, 2014

Megan McCain has been named as a Technology Review TR35, the “35 innovators under 35″ who are changing the world. Megan’s received this distinguished honor for her current work at USC and at the DBG in developing a “heart-on-a-chip”. To read more about the TR35, click here.

Summer Researchers – Many thanks for all your efforts!! August 26th, 2014

The DBG would like to thank all of our Summer Researchers who contributed to our research this summer and when disaster struck during torrential rains and the lab flooded, they came to help rescue our equipment and supplies. We had several REU students, cadets from West Point, HU undergraduates and in coming undergraduates, plus a couple of high school students. Thanks for all your efforts.

Featured Publications

68. Pasqualini FS, Sheehy SP, Agarwal A, Aratyn-Schaus Y, Parker KK. Structural Phenotyping of Stem Cell Derived Cardiomyocytes. Stem Cell Reports, 2015 [Epub ahead of print] Downloadable content: ImageJ script for the analysis of confocal images from differentiated , immature and mature neonate rat cardiomyocytes as well as hiPS-derived cardiomyocytes.

67. Nesmith AP, Agarwal A, McCain ML, Parker KK. Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation. Lab Chip, 2014, 14, 3925-3936.

66. Capulli AK, Tian K, Mehandru N, Bukhta A,, Choudhury SF, Suchyta M and Parker KK. Approaching the in vitro clinical trial: engineering organs on chips Lab Chip, 2014, 14, 3181 [Epub ahead of print]

65. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 May 11. doi: 10.1038/nm.3545. [Epub ahead of print]

64. McCain ML, Yuan H, Pasqualini FS, Campbell PH, Parker KK. Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. Am J Physiol Heart Circ Physiol. Jun 2014,306(11)H1525-H1539;DOI: 10.1152/ajpheart.00799.2013.

63. McCain ML, Agarwal A, Nesmith HW, Nesmith AP, Parker KK. Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues Biomaterials. 2014 Apr 11. pii: S0142-9612(14)00312-3. doi: 10.1016/j.biomaterials.2014.03.052. [Epub ahead of print]

62. Sheehy SP, Pasqualini F, Grosberg A, Park SJ, Yvonne Aratyn-Schaus Y, Parker KK. Quality Metrics for Stem Cell-Derived Cardiac Myocytes. Stem Cell Reports. 2014 Mar;2(3):282-294.