The Disease Biophysics Group (DBG) at Harvard University is an interdisciplinary team of biologists, physicists, engineers and material scientists actively researching the structure/function relationship in cardiac, neural, and vascular smooth muscle tissue engineering.
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What's New

Summer Researchers – Many thanks for all your efforts!! August 26th, 2014

The DBG would like to thank all of our Summer Researchers who contributed to our research this summer and when disaster struck during torrential rains and the lab flooded, they came to help rescue our equipment and supplies. We had several REU students, cadets from West Point, HU undergraduates and in coming undergraduates, plus a couple of high school students. Thanks for all your efforts.

Welcome to Lisa Scudder to the DBG! August 26th, 2014

The DBG would like to welcome our new Post-Doctoral Fellow, Lisa Scudder. Lisa joins us from laboratories of Professor Alfred L. George at Vanderbilt University, where she completed her Ph.D. in Pharmacology. We are excited about Lisa joining the team.

Congratulations for our new Ph.D.’s June 5th, 2014


L-R Sean Sheehy, Borna Dabiri, Professor Parker, Renita Horton and George Ye.

Postdoc Positions Open March 31st, 2014

The Disease Biophysics Group has three open postdoctoral positions to be filled in the summer of 2014:
1) One position in skeletal muscle tissue engineering,
2) One position in cardiac muscle tissue engineering, and
3) One position in nanofibers and materials science (no biology background required).
Competitive candidates should have an earned doctorate in an appropriate field and a record of first author publications. Candidates should submit, as a single PDF file, their cover letter, CV, and first author publications. Three letters of recommendation will be requested after initial screening of applications. Please send materials to Prof Parker, kkparker at seas dot harvard dot edu.

Congratulations to Dr. Leila Deravi!! March 10th, 2014

The DBG would like to congratulate Leila Deravi who has accepted a tenure track position at the University of New Hampshire. She will be an Assistant Professor of Analytical Chemistry and Materials Chemistry in the Department of Chemistry. Click here for more information. Please join the DBG in extending Leila a hearty congratulations!!

Featured Publications

67. Nesmith AP, Agarwal A, McCain ML, Parker KK. Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation. Lab Chip. DOI: 10.1039/c4lc00688g. [Epub ahead of print]

66. Capulli AK, Tian K, Mehandru N, Bukhta A,, Choudhury SF, Suchyta M and Parker KK. Approaching the in vitro clinical trial: engineering organs on chips Lab Chip, 2014, 14, 3181 [Epub ahead of print]

65. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 May 11. doi: 10.1038/nm.3545. [Epub ahead of print]

64. McCain ML, Yuan H, Pasqualini FS, Campbell PH, Parker KK. Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. Am J Physiol Heart Circ Physiol. Jun 2014,306(11)H1525-H1539;DOI: 10.1152/ajpheart.00799.2013.

63. McCain ML, Agarwal A, Nesmith HW, Nesmith AP, Parker KK. Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues Biomaterials. 2014 Apr 11. pii: S0142-9612(14)00312-3. doi: 10.1016/j.biomaterials.2014.03.052. [Epub ahead of print]

62. Sheehy SP, Pasqualini F, Grosberg A, Park SJ, Yvonne Aratyn-Schaus Y, Parker KK. Quality Metrics for Stem Cell-Derived Cardiac Myocytes. Stem Cell Reports. 2014 Mar;2(3):282-294.

61. Badrossamay MR, Balachandran K, Capulli AK, Golecki HM, Agarwal A, Goss JA, Kim H, Shin K, Parker KK. Engineering hybrid polymer-protein super-aligned nanofibers via rotary jet spinning. Biomaterials. 2014 Mar;35(10):3188-97.