The Disease Biophysics Group (DBG) at Harvard University is an interdisciplinary team of biologists, physicists, engineers and material scientists actively researching the structure/function relationship in cardiac, neural, and vascular smooth muscle tissue engineering.
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What's New

Welcome, Huibin! September 5th, 2018

The DBG welcomes Post-Doctoral Fellow Huibin Chang, who joined the group September 1. Huibin joins us from Georgia Tech, where he recently completed his Ph.D. in Materials Science and Engineering. Welcome, Huibin!

Congressional Staffers Visit the DBG August 31st, 2018

The DBG welcomed several opportunities so far in 2018 to discuss Federal budget appropriations to the National Institutes of Health and the Department of Defense. After discussions with staffers from Senator Elizabeth Warren (D-MA), Congresswoman Katherine Clark (D-MA), and the Senate Armed Services Committee regarding our experiences with the various offices of the DoD and NIH, we showed our work and introduced the professional staff and trainees within the laboratory. Over the years we have enjoyed interactions with a variety of elected officials and Congressional staffers who have requested to hear about our work and the challenges with funding research at the cutting edge.

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Farewell John August 20th, 2018

Congratulations to John P. Ferrier Jr., who was accepted into the Northeastern University Physics Ph.D. program in Boston. He moves to Northeastern in September 2018. Congratulations, John!

Farewell Sung Jin August 20th, 2018

Congratulations to Dr. Sung Jin Park, who accepted a position as an Assistant Professor of Biomedical Engineering at Georgia Tech and Emory University. He arrived in Atlanta in August 2018. Congratulations, Professor Park!

Farewell Charles Alver! August 13th, 2018

The DBG would like to thank Charles Alver for his time in the group and to wish him the best of luck in the Medical Scientist Training Program at the University of Miami!

Featured Publications

112. BM Maoz, A Herland, EA FitzGerald, T Grevesse, C Vidoudez, AR Pacheco, SP Sheehy, TE Park, S Dauth, R Mannix, N Budnik, K Shores, A Cho, JC Nawroth, D Segrè, B Budnik, DE Ingber, KK Parker, A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. Nat. Biotechnol. 2018 Aug 20. doi: 10.1038/nbt.4226

111. LA MacQueen, SP Sheehy, CO Chantre, JF Zimmerman, FS Pasqualini, X Liu, JA Goss, PH Campbell, GM Gonzalez, SJ Park, AK Capulli, JP Ferrier, TF Kosar, L Mahadevan, WT Pu, Parker KK, A tissue-engineered scale model of the heart ventricle. Nat. Biomed. Eng. 2018 July 23. doi: 10.1038/s41551-018-0271-5.

110. N R Sinatra, T Ranzani, J J Vlassak, Parker KK, and R J Wood Nanofiber-reinforced soft fluidic micro-actuators. J. Micromech. Microeng. 2018 May 21. doi: 10.1088/1361-6439/aab373.

109. Lee KY, Park S-J, Lee KA, Kim S-H, Kim H, Meroz Y, Mahadevan L, Jung K-H, Ahn TK, Parker KK, Shin K. Photosynthetic Artificial Organelles Sustain and Control ATP-Dependent Reactions in a Protocellular System. Nat Biotechnol. 2018 May 28. doi: 10.1038/nbt.4140.

108. Ahn S, Ardoña HAM, Lind JU, Eweje F, Kim SL, Gonzalez GM, Liu Q, Zimmerman JF, Pyrgiotakis G, Zhang Z, Beltran-Huarac J, Carpinone P, Moudgil BM, Demokritou P, Parker KK. Mussel-Inspired 3D Fiber Scaffolds for Heart-on-a-Chip Toxicity Studies of Engineered Nanomaterials. Anal Bioanal Chem. 2018 May 10. doi: 10.1007/s00216-018-1106-7; PubMed PMID: 29744562.

107. Pasqualini FS, Agarwal A, O’Connor BB, Liu Q, Sheehy SP, Parker KK. Traction force microscopy of engineered cardiac tissues. PLOS One. 2018 Mar 28;13(3):e0194706. doi: 10.1371/journal.pone.0194706; PubMed PMID: 29590169; PubMed Central PMCID: PMC5874032.

106. Chantre CO, Campbell PH, Golecki HM, Buganza AT, Capulli AK, Deravi LF, Dauth S, Sheehy SP, Paten JA, Gledhill K, Doucet YS, Abaci HE, Ahn S, Pope BD, Ruberti JW, Hoerstrup SP, Christiano AM, Parker KK Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model Biomaterials. 2018 Jun. doi: 10.1016/j.biomaterials.2018.03.006